ID   DEFB2_BUBBU             Reviewed;          40 AA.
AC   P85150;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Beta-defensin 2;
OS   Bubalus bubalis (Domestic water buffalo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bubalus.
OX   NCBI_TaxID=89462;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Milk {ECO:0000269|PubMed:18826332};
RX   PubMed=18826332; DOI=10.1177/026119290803600404;
RA   Das H., Swamy N., Sahoo G., Ahmed S.U., More T.;
RT   "Beta-defensin antibiotic peptides in the innate immunity of the buffalo:
RT   in vivo and in vitro studies.";
RL   Altern. Lab. Anim. 36:429-440(2008).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250|UniProtKB:P46171}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P46171}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P85150; -.
DR   SMR; P85150; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   CHAIN           1..40
FT                   /note="Beta-defensin 2"
FT                   /id="PRO_0000289145"
FT   DISULFID        7..36
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        14..29
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        19..37
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
SQ   SEQUENCE   40 AA;  4649 MW;  9DD6B4E125CEBE30 CRC64;
     VRNHVTCRIN RGFCVPIRCP GRTRQIGTCF GPRIKCCRSW