ID   DEFB2_MOUSE             Reviewed;          71 AA.
AC   P82020;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Beta-defensin 2;
DE            Short=BD-2;
DE            Short=mBD-2;
DE   AltName: Full=Defensin, beta 2;
DE   Flags: Precursor;
GN   Name=Defb2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=C57BL/6N; TISSUE=Kidney;
RX   PubMed=9923615; DOI=10.1016/s0014-5793(98)01630-5;
RA   Morrison G.M., Davidson D.J., Dorin J.R.;
RT   "A novel mouse beta defensin, Defb2, which is upregulated in the airways by
RT   lipopolysaccharide.";
RL   FEBS Lett. 442:112-116(1999).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Kidney, uterus and to a lesser extent in heart.
CC       {ECO:0000269|PubMed:9923615}.
CC   -!- INDUCTION: In tracheal epithelium, by lipopolysaccharide or
CC       inflammation. {ECO:0000269|PubMed:9923615}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AJ011800; CAB42815.1; -; mRNA.
DR   CCDS; CCDS40284.1; -.
DR   RefSeq; NP_034160.1; NM_010030.1.
DR   AlphaFoldDB; P82020; -.
DR   SMR; P82020; -.
DR   STRING; 10090.ENSMUSP00000006745; -.
DR   PaxDb; P82020; -.
DR   PRIDE; P82020; -.
DR   ProteomicsDB; 279365; -.
DR   DNASU; 13215; -.
DR   Ensembl; ENSMUST00000006745; ENSMUSP00000006745; ENSMUSG00000006570.
DR   GeneID; 13215; -.
DR   KEGG; mmu:13215; -.
DR   UCSC; uc009lca.1; mouse.
DR   CTD; 13215; -.
DR   MGI; MGI:1338754; Defb2.
DR   VEuPathDB; HostDB:ENSMUSG00000006570; -.
DR   GeneTree; ENSGT00940000165558; -.
DR   HOGENOM; CLU_189296_1_0_1; -.
DR   InParanoid; P82020; -.
DR   OMA; YCCKNIR; -.
DR   OrthoDB; 1584343at2759; -.
DR   PhylomeDB; P82020; -.
DR   BioGRID-ORCS; 13215; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Defb2; mouse.
DR   PRO; PR:P82020; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; P82020; protein.
DR   Bgee; ENSMUSG00000006570; Expressed in lobe of prostate and 32 other tissues.
DR   ExpressionAtlas; P82020; baseline and differential.
DR   Genevisible; P82020; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..71
FT                   /note="Beta-defensin 2"
FT                   /id="PRO_0000006927"
FT   DISULFID        37..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..67
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  7820 MW;  504A40E6369B3A0D CRC64;
     MRTLCSLLLI CCLLFSYTTP AVGSLKSIGY EAELDHCHTN GGYCVRAICP PSARRPGSCF
     PEKNPCCKYM K