ID   DEFB2_SHEEP             Reviewed;          64 AA.
AC   O19039;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Beta-defensin 2;
DE            Short=BD-2;
DE   AltName: Full=sBD2;
DE   Flags: Precursor;
GN   Name=DEFB2; Synonyms=BD2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9478010; DOI=10.1093/jn/128.2.297s;
RA   Huttner K.M., Brezinski-Caliguri D.J., Mahoney M.M., Diamond G.;
RT   "Antimicrobial peptide expression is developmentally regulated in the ovine
RT   gastrointestinal tract.";
RL   J. Nutr. 128:297S-299S(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Trachea;
RX   PubMed=9461419; DOI=10.1016/s0378-1119(97)00569-6;
RA   Huttner K.M., Lambeth M.R., Burkin H.R., Broad T.E.;
RT   "Localization and genomic organization of sheep antimicrobial peptides
RT   genes.";
RL   Gene 206:85-91(1998).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; U75251; AAB61996.1; -; Genomic_DNA.
DR   AlphaFoldDB; O19039; -.
DR   SMR; O19039; -.
DR   STRING; 9940.ENSOARP00000006894; -.
DR   Ensembl; ENSOART00000006999; ENSOARP00000006894; ENSOARG00000006442.
DR   Ensembl; ENSOART00020027463; ENSOARP00020022783; ENSOARG00020017835.
DR   Ensembl; ENSOART00020027536; ENSOARP00020022838; ENSOARG00020017835.
DR   Ensembl; ENSOART00020038339; ENSOARP00020031757; ENSOARG00020024503.
DR   Ensembl; ENSOART00020038364; ENSOARP00020031776; ENSOARG00020024512.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   OMA; HVTCRIN; -.
DR   Proteomes; UP000002356; Chromosome 26.
DR   Bgee; ENSOARG00000006442; Expressed in jejunum and 48 other tissues.
DR   ExpressionAtlas; O19039; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         23..64
FT                   /note="Beta-defensin 2"
FT                   /id="PRO_0000006964"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7078 MW;  C744942B364716C0 CRC64;
     MRLHHLLLVL FFVVLSAGSG FTHGVTDSLS CRWKKGICVL TRCPGTMRQI GTCFGPPVKC
     CRLK