DEFB3_BOVIN
ID DEFB3_BOVIN Reviewed; 57 AA.
AC P46161;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 3.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Beta-defensin 3;
DE AltName: Full=BNBD-3;
DE AltName: Full=BNDB-3;
DE Flags: Precursor; Fragment;
GN Name=DEFB3; Synonyms=BNDB3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Small intestine;
RX PubMed=9488394; DOI=10.1128/iai.66.3.1045-1056.1998;
RA Tarver A.P., Clark D.P., Diamond G., Russell J.P., Erdjument-Bromage H.,
RA Tempst P., Cohen K.S., Jones D.E., Sweeney R.W., Wines M., Hwang S.,
RA Bevins C.L.;
RT "Enteric beta-defensin: molecular cloning and characterization of a gene
RT with inducible intestinal epithelial cell expression associated with
RT Cryptosporidium parvum infection.";
RL Infect. Immun. 66:1045-1056(1998).
RN [2]
RP PROTEIN SEQUENCE OF 16-57, AND PYROGLUTAMATE FORMATION AT GLN-16.
RC STRAIN=Hereford; TISSUE=Neutrophil;
RX PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA Smith W., Henschen A.H., Cullor J.S.;
RT "Purification, primary structures, and antibacterial activities of beta-
RT defensins, a new family of antimicrobial peptides from bovine
RT neutrophils.";
RL J. Biol. Chem. 268:6641-6648(1993).
CC -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC S.aureus 502A.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF016396; AAC48803.1; -; Genomic_DNA.
DR AlphaFoldDB; P46161; -.
DR SMR; P46161; -.
DR InParanoid; P46161; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR Pfam; PF00711; Defensin_beta; 1.
DR SMART; SM00048; DEFSN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW Signal.
FT SIGNAL <1..?
FT /evidence="ECO:0000255"
FT PROPEP ?..15
FT /evidence="ECO:0000255"
FT /id="PRO_0000006880"
FT PEPTIDE 16..57
FT /note="Beta-defensin 3"
FT /id="PRO_0000006881"
FT MOD_RES 16
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:8454635"
FT DISULFID 24..53
FT /evidence="ECO:0000250"
FT DISULFID 31..46
FT /evidence="ECO:0000250"
FT DISULFID 36..54
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 57 AA; 6325 MW; 835CA5828E33F7C1 CRC64;
LALLFLVLSA GSGFTQGVRN HVTCRINRGF CVPIRCPGRT RQIGTCFGPR IKCCRSW
