DEFB3_MOUSE
ID DEFB3_MOUSE Reviewed; 63 AA.
AC Q9WTL0; Q29R78;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Beta-defensin 3;
DE Short=BD-3;
DE Short=mBD-3;
DE AltName: Full=Defensin, beta 3;
DE Flags: Precursor;
GN Name=Defb3; Synonyms=Bd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=10377137; DOI=10.1128/iai.67.7.3542-3547.1999;
RA Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C.,
RA Wilson J.M.;
RT "Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in
RT the epithelia of multiple organs.";
RL Infect. Immun. 67:3542-3547(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RC STRAIN=129/SvJ, C57BL/6J, and FVB/NJ; TISSUE=Lung;
RX PubMed=10922379; DOI=10.1074/jbc.m006603200;
RA Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F.,
RA Bevins C.L., McCray P.B. Jr.;
RT "A novel murine beta-defensin expressed in tongue, esophagus, and
RT trachea.";
RL J. Biol. Chem. 275:33314-33320(2000).
CC -!- FUNCTION: Antimicrobial activity against Gram-negative bacteria E.coli
CC and P.aeruginosa. {ECO:0000269|PubMed:10377137}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highest expression in salivary glands, epididymis,
CC ovary and pancreas and to a lesser extent in lung, liver and brain. Low
CC or no expression in skeletal muscle and tongue.
CC {ECO:0000269|PubMed:10377137, ECO:0000269|PubMed:10922379}.
CC -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:10377137}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC {ECO:0000305}.
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DR EMBL; AF093245; AAD29573.1; -; Genomic_DNA.
DR EMBL; AF092929; AAD29572.1; -; mRNA.
DR EMBL; BC114344; AAI14345.1; -; mRNA.
DR EMBL; BC116176; AAI16177.1; -; mRNA.
DR EMBL; BC116177; AAI16178.1; -; mRNA.
DR EMBL; BC134358; AAI34359.1; -; mRNA.
DR CCDS; CCDS40258.1; -.
DR RefSeq; NP_038784.1; NM_013756.2.
DR AlphaFoldDB; Q9WTL0; -.
DR SMR; Q9WTL0; -.
DR STRING; 10090.ENSMUSP00000033852; -.
DR TCDB; 1.C.85.1.8; the pore-forming Beta-defensin (Beta-defensin) family.
DR PaxDb; Q9WTL0; -.
DR PRIDE; Q9WTL0; -.
DR ProteomicsDB; 279191; -.
DR DNASU; 27358; -.
DR Ensembl; ENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
DR GeneID; 27358; -.
DR KEGG; mmu:27358; -.
DR UCSC; uc009lao.1; mouse.
DR CTD; 27358; -.
DR MGI; MGI:1351612; Defb3.
DR VEuPathDB; HostDB:ENSMUSG00000039775; -.
DR eggNOG; ENOG502T3P6; Eukaryota.
DR GeneTree; ENSGT00940000160995; -.
DR HOGENOM; CLU_189296_4_1_1; -.
DR InParanoid; Q9WTL0; -.
DR OMA; IRSGAIC; -.
DR OrthoDB; 1636401at2759; -.
DR PhylomeDB; Q9WTL0; -.
DR BioGRID-ORCS; 27358; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9WTL0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9WTL0; protein.
DR Bgee; ENSMUSG00000039775; Expressed in lip and 9 other tissues.
DR Genevisible; Q9WTL0; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..22
FT /evidence="ECO:0000255"
FT /id="PRO_0000006928"
FT PEPTIDE 23..63
FT /note="Beta-defensin 3"
FT /id="PRO_0000006929"
FT DISULFID 31..59
FT /evidence="ECO:0000250"
FT DISULFID 38..52
FT /evidence="ECO:0000250"
FT DISULFID 42..60
FT /evidence="ECO:0000250"
SQ SEQUENCE 63 AA; 7126 MW; 9D59BC8AD16EA330 CRC64;
MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG SCGVPFLKCC
KRK
