ID   DEFB3_RAT               Reviewed;          63 AA.
AC   Q32ZI4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Beta-defensin 3;
DE            Short=BD-3;
DE   AltName: Full=Defensin, beta 3;
DE   Flags: Precursor;
GN   Name=Defb3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621339; AAT51878.1; -; mRNA.
DR   RefSeq; NP_001032637.1; NM_001037548.1.
DR   AlphaFoldDB; Q32ZI4; -.
DR   SMR; Q32ZI4; -.
DR   PaxDb; Q32ZI4; -.
DR   GeneID; 641623; -.
DR   UCSC; RGD:1589572; rat.
DR   CTD; 27358; -.
DR   RGD; 1589572; Defb3.
DR   PRO; PR:Q32ZI4; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038126; Expressed in esophagus and 14 other tissues.
DR   ExpressionAtlas; Q32ZI4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..22
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000352691"
FT   PEPTIDE         23..63
FT                   /note="Beta-defensin 3"
FT                   /id="PRO_0000352692"
FT   DISULFID        31..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  7082 MW;  1F41AF1A07B2DB1F CRC64;
     MRIHYLLFSF LLVLLSPLSA FSKKVYNAVS CMTNGGICWL KCSGTFREIG SCGTRQLKCC
     KKK