DEFB4_RAT
ID DEFB4_RAT Reviewed; 63 AA.
AC O88514; Q32ZE9;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Beta-defensin 4;
DE Short=BD-4;
DE AltName: Full=BD-2;
DE AltName: Full=Defensin, beta 4;
DE AltName: Full=RBD-2;
DE AltName: Full=RBD-4;
DE Flags: Precursor;
GN Name=Defb4; Synonyms=Defb2, Defb3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=10456937; DOI=10.1128/iai.67.9.4827-4833.1999;
RA Jia H.P., Mills J.N., Barahmand-Pour F., Nishimura D., Mallampali R.K.,
RA Wang G., Wiles K., Tack B.F., Bevins C.L., McCray P.B. Jr.;
RT "Molecular cloning and characterization of rat genes encoding homologues of
RT human beta-defensins.";
RL Infect. Immun. 67:4827-4833(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
CC -!- FUNCTION: Exhibits antimicrobial activity against Gram-negative
CC bacteria and Gram-positive bacteria. May act as a ligand for C-C
CC chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity
CC of CCR6-expressing cells. {ECO:0000250|UniProtKB:P82019}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF068861; AAC28072.1; -; mRNA.
DR EMBL; AY621374; AAT51913.1; -; mRNA.
DR RefSeq; NP_071989.1; NM_022544.2.
DR AlphaFoldDB; O88514; -.
DR SMR; O88514; -.
DR STRING; 10116.ENSRNOP00000054838; -.
DR PaxDb; O88514; -.
DR Ensembl; ENSRNOT00000058029; ENSRNOP00000054838; ENSRNOG00000013939.
DR GeneID; 64389; -.
DR KEGG; rno:64389; -.
DR UCSC; RGD:619944; rat.
DR CTD; 56519; -.
DR RGD; 619944; Defb4.
DR eggNOG; ENOG502SYUI; Eukaryota.
DR GeneTree; ENSGT00940000160995; -.
DR HOGENOM; CLU_189296_4_1_1; -.
DR InParanoid; O88514; -.
DR OMA; IRSGAIC; -.
DR OrthoDB; 1630369at2759; -.
DR PhylomeDB; O88514; -.
DR Reactome; R-RNO-1461957; Beta defensins.
DR Reactome; R-RNO-1461973; Defensins.
DR PRO; PR:O88514; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000013939; Expressed in lung and 13 other tissues.
DR Genevisible; O88514; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:RGD.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..63
FT /note="Beta-defensin 4"
FT /id="PRO_0000006962"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P46162"
FT DISULFID 31..59
FT /evidence="ECO:0000250"
FT DISULFID 38..52
FT /evidence="ECO:0000250"
FT DISULFID 42..60
FT /evidence="ECO:0000250"
SQ SEQUENCE 63 AA; 6946 MW; 826099DE2144ACF4 CRC64;
MRIHYLLFSF LLVLLSPLSA FTQSINNPIT CLTKGGVCWG PCTGGFRQIG TCGLPRVRCC
KKK
