ID   DEFB5_MOUSE             Reviewed;          64 AA.
AC   Q9EPV9; F8VQA5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Beta-defensin 5;
DE            Short=BD-5;
DE            Short=mBD-5;
DE   AltName: Full=Defensin, beta 5;
DE   Flags: Precursor;
GN   Name=Defb5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Adler D.A., Holloway J.L., Haldeman B.E., Rixon M., Jaspers S., Fox B.,
RA   Gosink J., Sheppard P., Presnell S., Gao Z., Whitmore T., Stamm M.,
RA   Laube D., Diamond G.;
RT   "EST and genomic database mining yield novel human and mouse beta-
RT   defensins.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF318068; AAG49340.1; -; mRNA.
DR   EMBL; AC163997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS40257.1; -.
DR   RefSeq; NP_109659.2; NM_030734.2.
DR   AlphaFoldDB; Q9EPV9; -.
DR   SMR; Q9EPV9; -.
DR   STRING; 10090.ENSMUSP00000106391; -.
DR   PaxDb; Q9EPV9; -.
DR   PRIDE; Q9EPV9; -.
DR   DNASU; 81007; -.
DR   Ensembl; ENSMUST00000110763; ENSMUSP00000106391; ENSMUSG00000039785.
DR   GeneID; 81007; -.
DR   KEGG; mmu:81007; -.
DR   UCSC; uc009lan.1; mouse.
DR   CTD; 81007; -.
DR   MGI; MGI:1933153; Defb5.
DR   VEuPathDB; HostDB:ENSMUSG00000039785; -.
DR   GeneTree; ENSGT01030000235924; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; Q9EPV9; -.
DR   OrthoDB; 1861005at2759; -.
DR   PhylomeDB; Q9EPV9; -.
DR   BioGRID-ORCS; 81007; 0 hits in 69 CRISPR screens.
DR   PRO; PR:Q9EPV9; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9EPV9; protein.
DR   Bgee; ENSMUSG00000039785; Expressed in blastocyst and 4 other tissues.
DR   Genevisible; Q9EPV9; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..64
FT                   /note="Beta-defensin 5"
FT                   /id="PRO_0000006931"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
FT   CONFLICT        2
FT                   /note="K -> R (in Ref. 1; AAG49340)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        16
FT                   /note="S -> C (in Ref. 1; AAG49340)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        20..21
FT                   /note="GV -> SD (in Ref. 1; AAG49340)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        52
FT                   /note="S -> N (in Ref. 1; AAG49340)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   64 AA;  6970 MW;  7D7F84D1EB015D26 CRC64;
     MKIHYLLFAF LLVLLSPLAG VFSKTINNPV SCCMIGGICR YLCKGNILQN GSCGVTSLNC
     CKRK