ID   DEFB5_RAT               Reviewed;          63 AA.
AC   Q32ZI3;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Beta-defensin 5;
DE            Short=BD-5;
DE   AltName: Full=Defensin, beta 5;
DE   Flags: Precursor;
GN   Name=Defb5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621340; AAT51879.1; -; mRNA.
DR   RefSeq; NP_001032638.1; NM_001037549.1.
DR   AlphaFoldDB; Q32ZI3; -.
DR   SMR; Q32ZI3; -.
DR   STRING; 10116.ENSRNOP00000018655; -.
DR   Ensembl; ENSRNOT00000018653; ENSRNOP00000018655; ENSRNOG00000038126.
DR   GeneID; 641624; -.
DR   KEGG; rno:641624; -.
DR   UCSC; RGD:1563630; rat.
DR   CTD; 81007; -.
DR   RGD; 1563630; Defb5.
DR   eggNOG; ENOG502SYUI; Eukaryota.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; Q32ZI3; -.
DR   OMA; SCHRNKG; -.
DR   OrthoDB; 1584343at2759; -.
DR   PhylomeDB; Q32ZI3; -.
DR   PRO; PR:Q32ZI3; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038126; Expressed in esophagus and 14 other tissues.
DR   ExpressionAtlas; Q32ZI3; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR   GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR   GO; GO:0031640; P:killing of cells of another organism; ISO:RGD.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..63
FT                   /note="Beta-defensin 5"
FT                   /id="PRO_0000352693"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P46163"
FT   DISULFID        31..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6972 MW;  D0A43F1B8030647D CRC64;
     MRIHYLLFSF LLVLLSPLSV FTQSINNPVS CVTHGGICWG RCPGSFRQIG TCGLGKVRCC
     KKK