ID   DEFB6_BOVIN             Reviewed;          42 AA.
AC   P46164;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Beta-defensin 6;
DE   AltName: Full=BNBD-6;
DE   AltName: Full=BNDB-6;
GN   Name=DEFB6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   STRAIN=Hereford; TISSUE=Neutrophil;
RX   PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA   Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA   Smith W., Henschen A.H., Cullor J.S.;
RT   "Purification, primary structures, and antibacterial activities of beta-
RT   defensins, a new family of antimicrobial peptides from bovine
RT   neutrophils.";
RL   J. Biol. Chem. 268:6641-6648(1993).
CC   -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC       S.aureus 502A.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   PIR; F45495; F45495.
DR   AlphaFoldDB; P46164; -.
DR   SMR; P46164; -.
DR   PaxDb; P46164; -.
DR   PeptideAtlas; P46164; -.
DR   PRIDE; P46164; -.
DR   InParanoid; P46164; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   CHAIN           1..42
FT                   /note="Beta-defensin 6"
FT                   /id="PRO_0000064334"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8454635"
FT   DISULFID        9..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..31
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..39
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   42 AA;  4839 MW;  C9EA8E9B20DAEB97 CRC64;
     QGVRNHVTCR IYGGFCVPIR CPGRTRQIGT CFGRPVKCCR RW