DEFB6_MOUSE
ID DEFB6_MOUSE Reviewed; 63 AA.
AC Q91VD6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Beta-defensin 6;
DE Short=BD-6;
DE Short=mBD-6;
DE AltName: Full=Defensin, beta 6;
DE Flags: Precursor;
GN Name=Defb6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SYNTHESIS OF 23-63, FUNCTION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Skeletal muscle;
RX PubMed=11408484; DOI=10.1074/jbc.m104149200;
RA Yamaguchi Y., Fukuhara S., Nagase T., Tomita T., Hitomi S., Kimura S.,
RA Kurihara H., Ouchi Y.;
RT "A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal
RT muscle.";
RL J. Biol. Chem. 276:31510-31514(2001).
CC -!- FUNCTION: Has potent antibacterial activity against E.coli (ATCC
CC 25922). {ECO:0000269|PubMed:11408484}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle, also
CC expressed in esophagus, tongue, and trachea. Also expressed in lung
CC when induced by lipopolysaccharide. {ECO:0000269|PubMed:11408484}.
CC -!- INDUCTION: Expressed constitutively and induced by lipopolysaccharide
CC (LPS).
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AB063110; BAB61109.1; -; Genomic_DNA.
DR EMBL; AB063109; BAB61108.1; -; mRNA.
DR CCDS; CCDS40255.1; -.
DR RefSeq; NP_473415.1; NM_054074.1.
DR AlphaFoldDB; Q91VD6; -.
DR SMR; Q91VD6; -.
DR STRING; 10090.ENSMUSP00000060836; -.
DR PaxDb; Q91VD6; -.
DR PRIDE; Q91VD6; -.
DR DNASU; 116746; -.
DR Ensembl; ENSMUST00000063112; ENSMUSP00000060836; ENSMUSG00000050756.
DR GeneID; 116746; -.
DR KEGG; mmu:116746; -.
DR UCSC; uc009lal.1; mouse.
DR CTD; 116746; -.
DR MGI; MGI:2151044; Defb6.
DR VEuPathDB; HostDB:ENSMUSG00000050756; -.
DR GeneTree; ENSGT01030000235924; -.
DR HOGENOM; CLU_189296_4_1_1; -.
DR InParanoid; Q91VD6; -.
DR OrthoDB; 1584343at2759; -.
DR PhylomeDB; Q91VD6; -.
DR BioGRID-ORCS; 116746; 0 hits in 69 CRISPR screens.
DR PRO; PR:Q91VD6; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q91VD6; protein.
DR Bgee; ENSMUSG00000050756; Expressed in lip and 21 other tissues.
DR ExpressionAtlas; Q91VD6; baseline and differential.
DR Genevisible; Q91VD6; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:MGI.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..63
FT /note="Beta-defensin 6"
FT /id="PRO_0000006932"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P46164"
FT DISULFID 31..59
FT /evidence="ECO:0000250"
FT DISULFID 38..52
FT /evidence="ECO:0000250"
FT DISULFID 42..60
FT /evidence="ECO:0000250"
SQ SEQUENCE 63 AA; 6977 MW; 15FDAB06429D924E CRC64;
MKIHYLLFAF ILVMLSPLAA FSQLINSPVT CMSYGGSCQR SCNGGFRLGG HCGHPKIRCC
RRK
