ID   DEFB7_BOVIN             Reviewed;          62 AA.
AC   P46165; Q32P80;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Beta-defensin 7;
DE   AltName: Full=BNBD-7;
DE   AltName: Full=BNDB-7;
DE   Flags: Precursor;
GN   Name=DEFB7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 23-62, AND PYROGLUTAMATE FORMATION AT GLN-23.
RC   STRAIN=Hereford; TISSUE=Neutrophil;
RX   PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA   Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA   Smith W., Henschen A.H., Cullor J.S.;
RT   "Purification, primary structures, and antibacterial activities of beta-
RT   defensins, a new family of antimicrobial peptides from bovine
RT   neutrophils.";
RL   J. Biol. Chem. 268:6641-6648(1993).
CC   -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC       S.aureus 502A.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; BC108224; AAI08225.1; -; mRNA.
DR   PIR; G45495; G45495.
DR   RefSeq; NP_001095832.1; NM_001102362.2.
DR   AlphaFoldDB; P46165; -.
DR   SMR; P46165; -.
DR   STRING; 9913.ENSBTAP00000018930; -.
DR   PaxDb; P46165; -.
DR   PRIDE; P46165; -.
DR   Ensembl; ENSBTAT00000018930; ENSBTAP00000018930; ENSBTAG00000051383.
DR   GeneID; 768320; -.
DR   KEGG; bta:768320; -.
DR   CTD; 246080; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051383; -.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; P46165; -.
DR   OMA; HVTCRIN; -.
DR   OrthoDB; 1618911at2759; -.
DR   Reactome; R-BTA-1461957; Beta defensins.
DR   Reactome; R-BTA-1461973; Defensins.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000051383; Expressed in ascending colon and 63 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:8454635"
FT   PEPTIDE         23..62
FT                   /note="Beta-defensin 7"
FT                   /id="PRO_0000044723"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8454635"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  6964 MW;  34285A9567FEFF91 CRC64;
     MRLHHLLLAL LFLVLSAGSG FTQGVRNFVT CRINRGFCVP IRCPGHRRQI GTCLGPRIKC
     CR