DEFB7_MOUSE
ID DEFB7_MOUSE Reviewed; 71 AA.
AC Q91V70;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Beta-defensin 7;
DE Short=BD-7;
DE Short=mBD-7;
DE Short=mBD7;
DE AltName: Full=Defensin, beta 7;
DE Flags: Precursor;
GN Name=Defb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Lung;
RA Conejo-Garcia J.-R., Nehls M.C., Wattler S., Bals R., Heitland A.,
RA Kluever E., Liepke C., Adermann K., Forssmann W.-G.;
RT "Cloning and characterization of mBD-7 and mBD-8, two novel mouse beta-
RT defensins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP STRUCTURE BY NMR OF 26-62.
RX PubMed=11714914; DOI=10.1110/ps.24401;
RA Bauer F., Schweimer K., Kluever E., Conejo-Garcia J.-R., Forssmann W.-G.,
RA Roesch P., Adermann K., Sticht H.;
RT "Structure determination of human and murine beta-defensins reveals
RT structural conservation in the absence of significant sequence
RT similarity.";
RL Protein Sci. 10:2470-2479(2001).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ298147; CAC44541.1; -; mRNA.
DR EMBL; AJ298148; CAC44542.1; -; Genomic_DNA.
DR CCDS; CCDS40261.1; -.
DR RefSeq; NP_631966.1; NM_139220.1.
DR PDB; 1E4T; NMR; -; A=26-62.
DR PDBsum; 1E4T; -.
DR AlphaFoldDB; Q91V70; -.
DR SMR; Q91V70; -.
DR STRING; 10090.ENSMUSP00000045523; -.
DR PaxDb; Q91V70; -.
DR PRIDE; Q91V70; -.
DR DNASU; 246080; -.
DR Ensembl; ENSMUST00000047851; ENSMUSP00000045523; ENSMUSG00000037790.
DR GeneID; 246080; -.
DR KEGG; mmu:246080; -.
DR UCSC; uc009lar.1; mouse.
DR CTD; 246080; -.
DR MGI; MGI:2179200; Defb7.
DR VEuPathDB; HostDB:ENSMUSG00000037790; -.
DR GeneTree; ENSGT01030000235924; -.
DR HOGENOM; CLU_189296_4_1_1; -.
DR InParanoid; Q91V70; -.
DR OMA; INTPRAC; -.
DR OrthoDB; 1916627at2759; -.
DR PhylomeDB; Q91V70; -.
DR BioGRID-ORCS; 246080; 1 hit in 71 CRISPR screens.
DR EvolutionaryTrace; Q91V70; -.
DR PRO; PR:Q91V70; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q91V70; protein.
DR Bgee; ENSMUSG00000037790; Expressed in lumbar dorsal root ganglion and 19 other tissues.
DR Genevisible; Q91V70; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..25
FT /evidence="ECO:0000255"
FT /id="PRO_0000006933"
FT PEPTIDE 26..71
FT /note="Beta-defensin 7"
FT /id="PRO_0000006934"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P46165"
FT DISULFID 31..58
FT DISULFID 38..52
FT DISULFID 42..59
FT HELIX 31..34
FT /evidence="ECO:0007829|PDB:1E4T"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:1E4T"
FT STRAND 46..51
FT /evidence="ECO:0007829|PDB:1E4T"
FT STRAND 53..55
FT /evidence="ECO:0007829|PDB:1E4T"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:1E4T"
SQ SEQUENCE 71 AA; 8292 MW; 8FB7A8A89146DF60 CRC64;
MRIHYVLFAF LLVLLSPFAA FSQDINSKRA CYREGGECLQ RCIGLFHKIG TCNFRFKCCK
FQIPEKKTKI L
