ID   DEFB8_BOVIN             Reviewed;          38 AA.
AC   P46166;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Beta-defensin 8;
DE   AltName: Full=BNBD-8;
DE   AltName: Full=BNDB-8;
GN   Name=DEFB8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=Hereford; TISSUE=Neutrophil;
RX   PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA   Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA   Smith W., Henschen A.H., Cullor J.S.;
RT   "Purification, primary structures, and antibacterial activities of beta-
RT   defensins, a new family of antimicrobial peptides from bovine
RT   neutrophils.";
RL   J. Biol. Chem. 268:6641-6648(1993).
CC   -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC       S.aureus 502A.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   PIR; I45495; I45495.
DR   AlphaFoldDB; P46166; -.
DR   SMR; P46166; -.
DR   PeptideAtlas; P46166; -.
DR   PRIDE; P46166; -.
DR   InParanoid; P46166; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted.
FT   PEPTIDE         1..38
FT                   /note="Beta-defensin 8"
FT                   /id="PRO_0000044724"
FT   DISULFID        7..36
FT                   /evidence="ECO:0000250"
FT   DISULFID        14..29
FT                   /evidence="ECO:0000250"
FT   DISULFID        19..37
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   38 AA;  4359 MW;  C7B94D6C341270C2 CRC64;
     VRNFVTCRIN RGFCVPIRCP GHRRQIGTCL GPQIKCCR