ID   DEFB9_BOVIN             Reviewed;          55 AA.
AC   P46167; O18814;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 3.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Beta-defensin 9;
DE   AltName: Full=BNBD-9;
DE   AltName: Full=BNDB-9;
DE   Flags: Precursor; Fragment;
GN   Name=DEFB9; Synonyms=BNDB9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=9488394; DOI=10.1128/iai.66.3.1045-1056.1998;
RA   Tarver A.P., Clark D.P., Diamond G., Russell J.P., Erdjument-Bromage H.,
RA   Tempst P., Cohen K.S., Jones D.E., Sweeney R.W., Wines M., Hwang S.,
RA   Bevins C.L.;
RT   "Enteric beta-defensin: molecular cloning and characterization of a gene
RT   with inducible intestinal epithelial cell expression associated with
RT   Cryptosporidium parvum infection.";
RL   Infect. Immun. 66:1045-1056(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 16-55, AND PYROGLUTAMATE FORMATION AT GLN-16.
RC   STRAIN=Hereford; TISSUE=Neutrophil;
RX   PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA   Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA   Smith W., Henschen A.H., Cullor J.S.;
RT   "Purification, primary structures, and antibacterial activities of beta-
RT   defensins, a new family of antimicrobial peptides from bovine
RT   neutrophils.";
RL   J. Biol. Chem. 268:6641-6648(1993).
CC   -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC       S.aureus 502A.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF016394; AAC48801.1; -; mRNA.
DR   AlphaFoldDB; P46167; -.
DR   SMR; P46167; -.
DR   PRIDE; P46167; -.
DR   InParanoid; P46167; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          <1..?
FT                   /evidence="ECO:0000255"
FT   PROPEP          ?..15
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006884"
FT   PEPTIDE         16..55
FT                   /note="Beta-defensin 9"
FT                   /id="PRO_0000006885"
FT   MOD_RES         16
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8454635"
FT   DISULFID        24..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..54
FT                   /evidence="ECO:0000250"
FT   CONFLICT        48
FT                   /note="A -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   55 AA;  6049 MW;  48DAE6917DE366F2 CRC64;
     LALLFLVLSA GSGFTQGVRN FVTCRINRGF CVPIRCPGHR RQIGTCLAPQ IKCCR