DEFB9_MOUSE
ID DEFB9_MOUSE Reviewed; 67 AA.
AC Q8R2I6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Beta-defensin 9;
DE Short=BD-9;
DE Short=mBD-9;
DE AltName: Full=Defensin, beta 9;
DE Flags: Precursor;
GN Name=Defb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6N; TISSUE=Testis;
RX PubMed=12644567; DOI=10.1093/molbev/msg060;
RA Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT "Signal sequence conservation and mature peptide divergence within
RT subgroups of the murine beta-defensin gene family.";
RL Mol. Biol. Evol. 20:460-470(2003).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Weakly expressed in adult and neonatal brain.
CC {ECO:0000269|PubMed:12644567}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ437647; CAD26896.1; -; mRNA.
DR CCDS; CCDS40286.1; -.
DR RefSeq; NP_631965.1; NM_139219.2.
DR AlphaFoldDB; Q8R2I6; -.
DR SMR; Q8R2I6; -.
DR STRING; 10090.ENSMUSP00000054085; -.
DR PaxDb; Q8R2I6; -.
DR PRIDE; Q8R2I6; -.
DR DNASU; 246079; -.
DR Ensembl; ENSMUST00000057076; ENSMUSP00000054085; ENSMUSG00000047390.
DR GeneID; 246079; -.
DR KEGG; mmu:246079; -.
DR UCSC; uc009lcc.2; mouse.
DR CTD; 246079; -.
DR MGI; MGI:2179198; Defb9.
DR VEuPathDB; HostDB:ENSMUSG00000047390; -.
DR GeneTree; ENSGT01040000243029; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR InParanoid; Q8R2I6; -.
DR OMA; VSEMERC; -.
DR OrthoDB; 1841830at2759; -.
DR PhylomeDB; Q8R2I6; -.
DR BioGRID-ORCS; 246079; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Defb9; mouse.
DR PRO; PR:Q8R2I6; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R2I6; protein.
DR Bgee; ENSMUSG00000047390; Expressed in ciliary body and 29 other tissues.
DR ExpressionAtlas; Q8R2I6; baseline and differential.
DR Genevisible; Q8R2I6; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..67
FT /note="Beta-defensin 9"
FT /id="PRO_0000006937"
FT DISULFID 34..62
FT /evidence="ECO:0000250"
FT DISULFID 41..55
FT /evidence="ECO:0000250"
FT DISULFID 45..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 67 AA; 7682 MW; 35910A00DC8E1A74 CRC64;
MRTLCSLLLI CCLLFSYTTP AANSIIGVSE MERCHKKGGY CYFYCFSSHK KIGSCFPEWP
RCCKNIK
