ID   DEFB_MYTED              Reviewed;          35 AA.
AC   P81611;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Defensin-B;
DE   Flags: Fragment;
OS   Mytilus edulis (Blue mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC   Mytilus.
OX   NCBI_TaxID=6550;
RN   [1]
RP   PROTEIN SEQUENCE, CHARACTERIZATION, AND MASS SPECTROMETRY.
RC   TISSUE=Blood;
RX   PubMed=8702979; DOI=10.1074/jbc.271.36.21808;
RA   Charlet M., Chernysh S., Philippe H., Hetru C., Hoffman J.A., Bulet P.;
RT   "Innate immunity. Isolation of several cysteine-rich antimicrobial peptides
RT   from the blood of a mollusc, Mytilus edulis.";
RL   J. Biol. Chem. 271:21808-21813(1996).
CC   -!- FUNCTION: Has antibacterial activity against M.luteus and E.coli.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=4392.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:8702979};
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PRIDE; P81611; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   CHAIN           1..>35
FT                   /note="Defensin-B"
FT                   /id="PRO_0000074478"
FT   DISULFID        4..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        10..33
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        14..35
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   NON_TER         35
SQ   SEQUENCE   35 AA;  3884 MW;  5CF0E78E6DA1B8D3 CRC64;
     GFGCPNDYPC HRHCKSIPGR YGGYCGGXHR LRCTC