ID   DEFI6_DANRE             Reviewed;         612 AA.
AC   Q7SYB5; Q6TNU8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Differentially expressed in FDCP 6 homolog;
GN   Name=def6; ORFNames=si:dkey-6n6.5, zgc:63721;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ91231.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY391419; AAQ91231.1; ALT_FRAME; mRNA.
DR   EMBL; BX004884; CAK11143.1; -; Genomic_DNA.
DR   EMBL; BC054935; AAH54935.1; -; mRNA.
DR   RefSeq; NP_957334.1; NM_201040.1.
DR   AlphaFoldDB; Q7SYB5; -.
DR   SMR; Q7SYB5; -.
DR   STRING; 7955.ENSDARP00000025016; -.
DR   PaxDb; Q7SYB5; -.
DR   PRIDE; Q7SYB5; -.
DR   Ensembl; ENSDART00000005359; ENSDARP00000025016; ENSDARG00000012247.
DR   GeneID; 394015; -.
DR   KEGG; dre:394015; -.
DR   CTD; 394015; -.
DR   ZFIN; ZDB-GENE-040426-1246; def6a.
DR   eggNOG; ENOG502QUWV; Eukaryota.
DR   GeneTree; ENSGT00950000183017; -.
DR   HOGENOM; CLU_029358_1_0_1; -.
DR   InParanoid; Q7SYB5; -.
DR   OrthoDB; 1185498at2759; -.
DR   PhylomeDB; Q7SYB5; -.
DR   TreeFam; TF333160; -.
DR   Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR   Reactome; R-DRE-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DRE-9013404; RAC2 GTPase cycle.
DR   PRO; PR:Q7SYB5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000012247; Expressed in granulocyte and 25 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042074; P:cell migration involved in gastrulation; IMP:ZFIN.
DR   GO; GO:0060026; P:convergent extension; IMP:ZFIN.
DR   GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:ZFIN.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..612
FT                   /note="Differentially expressed in FDCP 6 homolog"
FT                   /id="PRO_0000294524"
FT   DOMAIN          211..307
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          546..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        215
FT                   /note="E -> R (in Ref. 1; AAQ91231)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   612 AA;  72091 MW;  778DBDC5FBEBB689 CRC64;
     MDLRSELLKS IWYAFTALDV EKSGKVSKSQ LKVLSHNLYT VLKIPHEAAA LEEHFRDDDD
     GPVSSQGYMP YLNKYILDKV VEGTFVKENV DELCWTLTAK KNYRPEGKSI LPAKDAFRLW
     CLFIFLSEDR YPLVMIPDEV EYLLKKFCMA MSVELNYVEL EDFISQDSVQ QNGFTVWTFL
     EMMNSGKLTR GIAKETVSMA IEEVYREIVG DVLKEGYLWK KGQLRRNWTE RWFTLRPSTL
     LYFTSEDRKD HKGNIQLDGN CCVEVLPDRD GKRCMFCLKT LTKTYELSAS DTKQRQEWTT
     AIQTAIRLYV EGKTSLHKDL KLKRRDQREQ REKRREAKEQ ELQRLRALQE ERERKMAELE
     LLKEAQRQAQ AMLEQDEQRR RQQHEQLHQA LEIQLKEAEE ARASMQAEMA LKEAEAEKQR
     TRIRELEAMQ QRLEDALQQE IKARQDEEAF RYAQARLLAE EEEKMKALMG LREEQEEYIQ
     RAQREKQELR QEMESKSRAL EEAQRQLEET RANRYRVDQD VVAAQRKLRQ ASTNVKHWNV
     QMNRLMHPIG PGEKRSSGGS FSSFRIPSQK DPALRQKQKS EEQDEESKEN MESRGGCEAD
     RRLSTNGQME IP