DEFI8_DROME
ID DEFI8_DROME Reviewed; 492 AA.
AC Q9VTT9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Differentially expressed in FDCP 8 homolog {ECO:0000305};
GN Name=DEF8 {ECO:0000312|FlyBase:FBgn0046296};
GN ORFNames=CG11534 {ECO:0000312|FlyBase:FBgn0046296};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the DEF8 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49957.1; -; Genomic_DNA.
DR EMBL; AY058352; AAL13581.1; -; mRNA.
DR RefSeq; NP_648549.1; NM_140292.3.
DR AlphaFoldDB; Q9VTT9; -.
DR SMR; Q9VTT9; -.
DR BioGRID; 64736; 12.
DR IntAct; Q9VTT9; 10.
DR STRING; 7227.FBpp0075727; -.
DR PaxDb; Q9VTT9; -.
DR PRIDE; Q9VTT9; -.
DR DNASU; 39381; -.
DR EnsemblMetazoa; FBtr0075995; FBpp0075727; FBgn0046296.
DR GeneID; 39381; -.
DR KEGG; dme:Dmel_CG11534; -.
DR UCSC; CG11534-RA; d. melanogaster.
DR CTD; 54849; -.
DR FlyBase; FBgn0046296; DEF8.
DR VEuPathDB; VectorBase:FBgn0046296; -.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000159182; -.
DR HOGENOM; CLU_034500_4_0_1; -.
DR InParanoid; Q9VTT9; -.
DR OMA; IEPRLCD; -.
DR OrthoDB; 177737at2759; -.
DR PhylomeDB; Q9VTT9; -.
DR SignaLink; Q9VTT9; -.
DR BioGRID-ORCS; 39381; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG11534; fly.
DR GenomeRNAi; 39381; -.
DR PRO; PR:Q9VTT9; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0046296; Expressed in embryonic/larval hemocyte (Drosophila) and 23 other tissues.
DR Genevisible; Q9VTT9; DM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00029; C1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; Zf-RING_9.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; zf-RING_9; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SUPFAM; SSF57889; SSF57889; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..492
FT /note="Differentially expressed in FDCP 8 homolog"
FT /id="PRO_0000321920"
FT ZN_FING 161..214
FT /note="Phorbol-ester/DAG-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT ZN_FING 400..453
FT /note="Phorbol-ester/DAG-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT REGION 38..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..492
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55408 MW; 280D3E1E6ACDC93C CRC64;
MSSWKDSLTS IPGTVAQLIN ESASNLLHAS STLGSTVGLG GSGSTGSGSE AGGSEESGPQ
GAEYRALPIP ASLVREQWRL IFTSDANIQD LQAAIAHCRD LVLLSEELSE ERRWLVRHLV
DLRYSLQELE EAQEQHSLSS DMVVMNAIRA VVGHHFVPHH PHHGKRNRLQ AAAKRNYCDH
CTTIIWSVVQ NSYVCSDCGF LVHQKCIDGV KRVCAHVLVS ERQHPISEIC PEIGLASQGY
KCAECGTMLN IKNTWIEPRL CDYSGLYYCP RCNWNDSNFI PARIIHNWDF SPRRVSRTAL
QEIRLFLNKP LIRLEEDNPK LFVFVEKLCA VKKLRQNLVH MRHYLAACKI ASELKLVDQQ
LGVRRHLAQS NEFYSLSDLS QVESGALSEF LQGVFKAFND HIRSCPMCLA QAYICEICSN
NEVIFPFDDG CIKCDQCNSI FHRVCLTRKN MICPKCIRIQ ERRLQLDRMK STEDDDDDDD
GVATDDDVTA AE
