ID   DEFI8_XENTR             Reviewed;         443 AA.
AC   Q6DJB3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Differentially expressed in FDCP 8 homolog;
DE            Short=DEF-8;
GN   Name=def8;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates lysosome peripheral distribution and
CC       ruffled border formation in osteoclasts. Involved in bone resorption.
CC       {ECO:0000250|UniProtKB:Q99J78}.
CC   -!- SIMILARITY: Belongs to the DEF8 family. {ECO:0000305}.
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DR   EMBL; BC075269; AAH75269.1; -; mRNA.
DR   RefSeq; NP_001004881.1; NM_001004881.1.
DR   AlphaFoldDB; Q6DJB3; -.
DR   SMR; Q6DJB3; -.
DR   STRING; 8364.ENSXETP00000056753; -.
DR   DNASU; 448211; -.
DR   GeneID; 448211; -.
DR   KEGG; xtr:448211; -.
DR   CTD; 54849; -.
DR   Xenbase; XB-GENE-967882; def8.
DR   eggNOG; KOG1829; Eukaryota.
DR   InParanoid; Q6DJB3; -.
DR   OrthoDB; 177737at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023412; Expressed in testis and 12 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0045780; P:positive regulation of bone resorption; ISS:UniProtKB.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR036280; Multihaem_cyt_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR025258; Zf-RING_9.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF13901; zf-RING_9; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM01175; DUF4206; 1.
DR   SUPFAM; SSF48695; SSF48695; 1.
DR   SUPFAM; SSF57889; SSF57889; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..443
FT                   /note="Differentially expressed in FDCP 8 homolog"
FT                   /id="PRO_0000321918"
FT   ZN_FING         134..185
FT                   /note="Phorbol-ester/DAG-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   ZN_FING         364..424
FT                   /note="Phorbol-ester/DAG-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   REGION          14..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  51439 MW;  76C70C47A80F68BF CRC64;
     MEYDDKLVRF RQGHLNPFDK QGEAERQPAA CETEPSKDFP TSSPLSVPEF HCPDRVMDLG
     VSEDHFSRPV GLFLASDIQQ LRQAIEECKQ EILELPEHSD RQKDAVVRLI HLRLKLQELN
     DPLEDEPNLR ILLEHRFYKE KSKSVKHLCD KCSTFIWGLI QTWYTCTGCS YRCHSKCLNL
     ITKPCVRSKV SHQAEYELSI CPEAGLDSQD YRCAECRTPI SLRSVPSEAR QCDYTGQYYC
     ISCHWNDIAV IPARAIHNWD FEPHKVSRCS MRYLALMLGR PVLKLREINP LLFNYVEELV
     EIRKLRQDIL LMKPYFITCK EAMEARLLLQ LQDRQHFVEN DDMYSLQDLL DISSGRLGCS
     LTEIHTTFAK HIKLDCERCQ AKGFVCELCK EGDILFPFDS HTSVCQDCAA VFHRDCYYDN
     STSCPRCTRL NLRKQVQNPG EEP