ID   DEFI_AESCY              Reviewed;          38 AA.
AC   P80154;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Defensin {ECO:0000303|PubMed:1425705};
OS   Aeshna cyanea (Southern hawker dragonfly) (Libellula cyanea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Palaeoptera; Odonata; Epiprocta; Anisoptera; Aeshnidae; Aeshna.
OX   NCBI_TaxID=12921;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Hemolymph;
RX   PubMed=1425705; DOI=10.1111/j.1432-1033.1992.tb17371.x;
RA   Bulet P., Cociancich S., Reuland M., Sauber F., Bischoff R., Hegy G.,
RA   van Dorsselaer A., Hetru C., Hoffmann J.A.;
RT   "A novel insect defensin mediates the inducible antibacterial activity in
RT   larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata).";
RL   Eur. J. Biochem. 209:977-984(1992).
CC   -!- FUNCTION: Mediates the inducible antibacterial activity in larvae of
CC       A.cyanea. {ECO:0000269|PubMed:1425705}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1425705}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   PIR; S27242; S27242.
DR   AlphaFoldDB; P80154; -.
DR   SMR; P80154; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..38
FT                   /note="Defensin"
FT                   /evidence="ECO:0000269|PubMed:1425705"
FT                   /id="PRO_0000044710"
FT   DISULFID        4..26
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
FT   DISULFID        11..34
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
FT   DISULFID        15..36
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
SQ   SEQUENCE   38 AA;  4180 MW;  7C884A8FDF54A46A CRC64;
     GFGCPLDQMQ CHRHCQTITG RSGGYCSGPL KLTCTCYR