ID   DEFI_BOMPA              Reviewed;          51 AA.
AC   P81462;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Defensin;
OS   Bombus pascuorum (Common carder bumblebee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Bombus; Thoracobombus.
OX   NCBI_TaxID=65598;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT PHE-51, AND MASS SPECTROMETRY.
RC   TISSUE=Hemolymph;
RX   PubMed=9219367; DOI=10.1016/s0965-1748(97)00013-1;
RA   Rees J.A., Moniatte M., Bulet P.;
RT   "Novel antibacterial peptides isolated from a European bumblebee, Bombus
RT   pascuorum (Hymenoptera, Apoidea).";
RL   Insect Biochem. Mol. Biol. 27:413-422(1997).
CC   -!- FUNCTION: Antibacterial peptide against Gram-positive and Gram-negative
CC       bacteria and fungi.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: By bacterial infection.
CC   -!- MASS SPECTROMETRY: Mass=5529.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9219367};
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   AlphaFoldDB; P81462; -.
DR   SMR; P81462; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR017982; Defensin_insect.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   PRINTS; PR00271; DEFENSIN.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Immunity; Innate immunity; Secreted.
FT   CHAIN           1..51
FT                   /note="Defensin"
FT                   /id="PRO_0000074471"
FT   MOD_RES         51
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9219367"
FT   DISULFID        3..31
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        17..36
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        21..38
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   51 AA;  5536 MW;  6DB7B5A879DD8C1A CRC64;
     VTCDLLSIKG VAEHSACAAN CLSMGKAGGR CENGICLCRK TTFKELWDKR F