ID   DEFI_ORNCO              Reviewed;          44 AA.
AC   B2D2C0;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Defensin {ECO:0000312|EMBL:ACB70361.1};
OS   Ornithodoros coriaceus (Soft tick) (Argasid tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Argasidae; Ornithodoros.
OX   NCBI_TaxID=92741;
RN   [1] {ECO:0000312|EMBL:ACB70361.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland {ECO:0000312|EMBL:ACB70361.1};
RX   PubMed=18725333; DOI=10.1016/j.jprot.2008.07.006;
RA   Francischetti I.M., Meng Z., Mans B.J., Gudderra N., Hall M.,
RA   Veenstra T.D., Pham V.M., Kotsyfakis M., Ribeiro J.M.;
RT   "An insight into the salivary transcriptome and proteome of the soft tick
RT   and vector of epizootic bovine abortion, Ornithodoros coriaceus.";
RL   J. Proteomics 71:493-512(2008).
CC   -!- FUNCTION: Antibacterial peptide mostly active against Gram-positive
CC       bacteria. {ECO:0000250|UniProtKB:Q86QI5, ECO:0000255|PROSITE-
CC       ProRule:PRU00710}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86QI5,
CC       ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; EU574854; ACB70361.1; -; mRNA.
DR   AlphaFoldDB; B2D2C0; -.
DR   SMR; B2D2C0; -.
DR   PRIDE; B2D2C0; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Immunity;
KW   Innate immunity; Secreted.
FT   CHAIN           1..44
FT                   /note="Defensin"
FT                   /id="PRO_0000394188"
FT   DISULFID        10..31
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
FT   DISULFID        17..39
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
FT   DISULFID        21..41
FT                   /evidence="ECO:0000250|UniProtKB:I1T3C7"
SQ   SEQUENCE   44 AA;  4891 MW;  0ADAC20995064311 CRC64;
     MVRARRGCGC PLNQGACHRH CKSIGRRGGY CAGFLKQTCT CYRN