ID   DEFI_ORYRH              Reviewed;          79 AA.
AC   O96049;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Defensin {ECO:0000303|PubMed:10561605};
DE   Flags: Precursor;
OS   Oryctes rhinoceros (Coconut rhinoceros beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Dynastinae; Oryctes.
OX   NCBI_TaxID=72550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-51, FUNCTION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RC   TISSUE=Fat body, and Hemolymph;
RX   PubMed=10561605; DOI=10.1046/j.1432-1327.1999.00906.x;
RA   Ishibashi J., Yang J., Saido-Sakanaka H., Nakazawa H., Yamamoto M.,
RA   Yamakawa M.;
RT   "Purification, cDNA cloning and modification of a defensin from the coconut
RT   rhinoceros beetle, Oryctes rhinoceros.";
RL   Eur. J. Biochem. 266:616-623(1999).
CC   -!- FUNCTION: Shows very strong activity against S.aureus.
CC       {ECO:0000269|PubMed:10561605}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:10561605}.
CC   -!- TISSUE SPECIFICITY: Fat body, hemocytes, malpighian tubules and midgut.
CC       {ECO:0000269|PubMed:10561605}.
CC   -!- INDUCTION: By bacterial infection in fat body, hemocytes and malpighian
CC       tubules. {ECO:0000269|PubMed:10561605}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; AB011245; BAA36401.1; -; mRNA.
DR   AlphaFoldDB; O96049; -.
DR   SMR; O96049; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR017982; Defensin_insect.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   PRINTS; PR00271; DEFENSIN.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..36
FT                   /evidence="ECO:0000305|PubMed:10561605"
FT                   /id="PRO_0000006744"
FT   CHAIN           37..79
FT                   /note="Defensin"
FT                   /evidence="ECO:0000305|PubMed:10561605"
FT                   /id="PRO_0000006745"
FT   DISULFID        39..70
FT                   /evidence="ECO:0000250|UniProtKB:A9XFZ7"
FT   DISULFID        56..75
FT                   /evidence="ECO:0000250|UniProtKB:A9XFZ7"
FT   DISULFID        60..77
FT                   /evidence="ECO:0000250|UniProtKB:A9XFZ7"
SQ   SEQUENCE   79 AA;  8394 MW;  8D8A3EF8CBD34A83 CRC64;
     MSRFIVFAFI VAMCIAHSLA APAPEALEAS VIRQKRLTCD LLSFEAKGFA ANHSLCAAHC
     LAIGRKGGAC QNGVCVCRR