ID   DEFI_PYRAP              Reviewed;          43 AA.
AC   P37364; P80308;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Defensin;
OS   Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Pentatomomorpha; Pyrrhocoroidea; Pyrrhocoridae; Pyrrhocoris.
OX   NCBI_TaxID=37000;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hemolymph;
RX   PubMed=8002963; DOI=10.1042/bj3000567;
RA   Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C.,
RA   Hoffmann J.A., Bulet P.;
RT   "Novel inducible antibacterial peptides from a hemipteran insect, the sap-
RT   sucking bug Pyrrhocoris apterus.";
RL   Biochem. J. 300:567-575(1994).
CC   -!- FUNCTION: Antibacterial peptide. Affects Gram-positive bacteria
CC       M.luteus, B.megaterium, A.viridans, S.aureus and S.saprophyticus.
CC       Moderate activity against P.acidilactici and B.subtilis QB935. Also
CC       affects Gram-negative bacterium, D22 form of E.coli.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   PIR; S44463; S44463.
DR   AlphaFoldDB; P37364; -.
DR   SMR; P37364; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Immunity; Innate immunity; Secreted.
FT   CHAIN           1..43
FT                   /note="Defensin"
FT                   /id="PRO_0000074474"
FT   DISULFID        3..34
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        20..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        24..41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   43 AA;  4735 MW;  69E6344C758E3F00 CRC64;
     ATCDILSFQS QWVTPNHAGC ALHCVIKGYK GGQCKITVCH CRR