ID   DEFI_TENMO              Reviewed;          84 AA.
AC   Q27023;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Tenecin-1;
DE   Flags: Precursor;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 49-59, AND DISULFIDE BONDS.
RC   TISSUE=Larval hemolymph;
RX   PubMed=7798186; DOI=10.1093/oxfordjournals.jbchem.a124502;
RA   Moon H.J., Lee S.Y., Kurata S., Natori S., Lee B.L.;
RT   "Purification and molecular cloning of cDNA for an inducible antibacterial
RT   protein from larvae of the coleopteran, Tenebrio molitor.";
RL   J. Biochem. 116:53-58(1994).
CC   -!- FUNCTION: Bactericidal protein produced in response to injury. It is
CC       cytotoxic to Gram-positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; D17670; BAA04552.1; -; mRNA.
DR   PIR; JX0332; JX0332.
DR   AlphaFoldDB; Q27023; -.
DR   TCDB; 1.C.47.1.4; the insect/fungal defensin (insect/fungal defensin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd00107; Knot1; 1.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Direct protein sequencing; Disulfide bond; Immunity; Innate immunity;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..41
FT                   /id="PRO_0000006754"
FT   CHAIN           42..84
FT                   /note="Tenecin-1"
FT                   /id="PRO_0000006755"
FT   DISULFID        44..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710,
FT                   ECO:0000269|PubMed:7798186"
FT   DISULFID        61..81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710,
FT                   ECO:0000269|PubMed:7798186"
FT   DISULFID        65..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710,
FT                   ECO:0000269|PubMed:7798186"
SQ   SEQUENCE   84 AA;  9176 MW;  0367C5070468BE60 CRC64;
     MKLTIFALVA CFFILQIAAF PLEEAATAEE IEQGEHIRVK RVTCDILSVE AKGVKLNDAA
     CAAHCLFRGR SGGYCNGKRV CVCR