ID   DEFI_TRYDI              Reviewed;          43 AA.
AC   Q10745;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Defensin;
OS   Trypoxylus dichotomus (Japanese rhinoceros beetle) (Allomyrina dichotoma).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Dynastinae; Trypoxylus.
OX   NCBI_TaxID=273928;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Hemolymph;
RX   PubMed=8607799; DOI=10.1006/bbrc.1996.0438;
RA   Miyanoshita A., Hara S., Sugiyama M., Asaoka A., Taniai K., Yukuhiro F.,
RA   Yamakawa M.;
RT   "Isolation and characterization of a new member of the insect defensin
RT   family from a beetle, Allomyrina dichotoma.";
RL   Biochem. Biophys. Res. Commun. 220:526-531(1996).
CC   -!- FUNCTION: Antibacterial peptide. Affects Gram-negative bacteria
CC       including methicillin-resistant Staphylococcus aureus.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: By bacterial infection.
CC   -!- MASS SPECTROMETRY: Mass=4542; Mass_error=1.4; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8607799};
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   AlphaFoldDB; Q10745; -.
DR   SMR; Q10745; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR017982; Defensin_insect.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   PRINTS; PR00271; DEFENSIN.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Immunity; Innate immunity; Secreted.
FT   CHAIN           1..43
FT                   /note="Defensin"
FT                   /id="PRO_0000074468"
FT   DISULFID        3..34
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        20..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        24..41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   43 AA;  4553 MW;  5407246E9E673941 CRC64;
     VTCDLLSFEA KGFAANHSLC AAHCLAIGRR GGSCERGVCI CRR