ID   DEF_FORAQ               Reviewed;          95 AA.
AC   Q5BU36;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Defensin {ECO:0000250|UniProtKB:P91793};
DE   Flags: Precursor;
OS   Formica aquilonia (Red wood ant) (Scottish wood ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Formicinae; Formica.
OX   NCBI_TaxID=258703;
RN   [1] {ECO:0000312|EMBL:AAX20157.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=16033427; DOI=10.1111/j.1365-2583.2005.00564.x;
RA   Viljakainen L., Pamilo P.;
RT   "Identification and molecular characterization of defensin gene from the
RT   ant Formica aquilonia.";
RL   Insect Mol. Biol. 14:335-338(2005).
CC   -!- FUNCTION: Antibacterial peptide mostly active against Gram-positive
CC       bacteria. {ECO:0000250|UniProtKB:P91793, ECO:0000255|PROSITE-
CC       ProRule:PRU00710}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P91793,
CC       ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY875719; AAX20157.1; -; mRNA.
DR   EMBL; AY875720; AAX20158.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5BU36; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..55
FT                   /evidence="ECO:0000250|UniProtKB:P91793, ECO:0000255"
FT                   /id="PRO_0000383669"
FT   CHAIN           56..95
FT                   /note="Defensin"
FT                   /evidence="ECO:0000250|UniProtKB:P91793"
FT                   /id="PRO_0000383670"
FT   DISULFID        58..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        71..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        75..93
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   95 AA;  10454 MW;  5CF121F965E18502 CRC64;
     MKNYVFALLV VTAVAIALPN EDKNAPMRVH LLPQKEDESL KLEVTPVKEH HRTRRFTCDL
     LSGAGVDHSA CAAHCILRGK TGGRCNSDRV CVCRA