ID   DEF_MAMBR               Reviewed;          98 AA.
AC   Q8WQZ3;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Defensin {ECO:0000303|PubMed:12753953, ECO:0000312|EMBL:AAL69980.2};
DE   Flags: Precursor;
OS   Mamestra brassicae (Cabbage moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Hadeninae; Mamestra.
OX   NCBI_TaxID=55057 {ECO:0000312|EMBL:AAL69980.2};
RN   [1] {ECO:0000312|EMBL:AAL69980.2}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX   PubMed=12753953; DOI=10.1016/s0248-4900(02)01219-4;
RA   Mandrioli M., Bugli S., Saltini S., Genedani S., Ottaviani E.;
RT   "Molecular characterization of a defensin in the IZD-MB-0503 cell line
RT   derived from immunocytes of the insect Mamestra brassicae (Lepidoptera).";
RL   Biol. Cell 95:53-57(2003).
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:12753953}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; AF465486; AAL69980.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WQZ3; -.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; IEP:UniProtKB.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Immunity;
KW   Innate immunity; Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..98
FT                   /note="Defensin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000445348"
FT   DISULFID        61..88
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        74..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        78..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   98 AA;  10809 MW;  196C459995FD722C CRC64;
     MLCLADIRIV ASCSAAIKSG YGQQPWLAHV AGPYANSLFD DVPADSYHAA VEYLRLIPAS
     CYLLDGYAAG RDDCRAHCIA PRNRRLYCAS YQVCVCRY