ID   DEF_PHACN               Reviewed;          10 AA.
AC   P84785;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Defensin-like protein;
DE   AltName: Full=Coccinin;
DE   Flags: Fragment;
OS   Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX   NCBI_TaxID=3886;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   STRAIN=cv. Major {ECO:0000269|PubMed:15572193};
RC   TISSUE=Seed {ECO:0000269|PubMed:15572193};
RX   PubMed=15572193; DOI=10.1016/j.peptides.2004.08.003;
RA   Ngai P.H., Ng T.B.;
RT   "Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse
RT   transcriptase inhibitory activities from large scarlet runner beans.";
RL   Peptides 25:2063-2068(2004).
CC   -!- FUNCTION: Has strong antifungal activity against F.oxysporum,
CC       M.arachidicola and P.piricola, and weaker antifungal activity against
CC       B.cinerea, C.comatus and R.solani. Exerts antifungal activity against
CC       M.arachidicola with an IC(50) of 75 uM. Inhibits the proliferation of
CC       leukemia cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-
CC       1) reverse transcriptase. Lacks mitogenic activity towards murine
CC       splenocytes. {ECO:0000269|PubMed:15572193}.
CC   -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
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DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fungicide; Plant defense.
FT   PEPTIDE         1..>10
FT                   /note="Defensin-like protein"
FT                   /id="PRO_0000225611"
FT   NON_TER         10
FT                   /evidence="ECO:0000303|PubMed:15572193"
SQ   SEQUENCE   10 AA;  1182 MW;  8B4C0DADD7244B01 CRC64;
     KQTENLADTY