ID   DEF_TITDI               Reviewed;          36 AA.
AC   P0CF77;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 16.
DE   RecName: Full=Tddefensin {ECO:0000303|PubMed:19470401};
OS   Tityus discrepans (Venezuelan scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=57059;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19470401; DOI=10.1016/j.biochi.2009.05.005;
RA   D'Suze G., Schwartz E.F., Garcia-Gomez B.I., Sevcik C., Possani L.D.;
RT   "Molecular cloning and nucleotide sequence analysis of genes from a cDNA
RT   library of the scorpion Tityus discrepans.";
RL   Biochimie 91:1010-1019(2009).
CC   -!- FUNCTION: Antibacterial peptide mostly active against Gram-positive
CC       bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19470401}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:19470401}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CF77; -.
DR   SMR; P0CF77; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted.
FT   CHAIN           1..36
FT                   /note="Tddefensin"
FT                   /evidence="ECO:0000305|PubMed:19470401"
FT                   /id="PRO_0000394021"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:A0A384E0Y8"
FT   DISULFID        10..32
FT                   /evidence="ECO:0000250|UniProtKB:A0A384E0Y8"
FT   DISULFID        14..34
FT                   /evidence="ECO:0000250|UniProtKB:A0A384E0Y8"
SQ   SEQUENCE   36 AA;  4198 MW;  B4BEF1E926504EFE CRC64;
     RYCPRNPEAC YNYCLRTGRP GGYCGGRSRI TCFCFR