DEF_VIGUS
ID DEF_VIGUS Reviewed; 10 AA.
AC P84868;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 25-MAY-2022, entry version 21.
DE RecName: Full=Defensin-like protein;
DE AltName: Full=Sesquin;
DE Flags: Fragment;
OS Vigna unguiculata subsp. sesquipedalis (Yard-Long bean) (Vigna
OS sesquipedalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=138955;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND FUNCTION.
RC STRAIN=cv. Ground bean {ECO:0000269|PubMed:15949629};
RC TISSUE=Seed {ECO:0000269|PubMed:15949629};
RX PubMed=15949629; DOI=10.1016/j.peptides.2005.01.003;
RA Wong J.H., Ng T.B.;
RT "Sesquin, a potent defensin-like antimicrobial peptide from ground beans
RT with inhibitory activities toward tumor cells and HIV-1 reverse
RT transcriptase.";
RL Peptides 26:1120-1126(2005).
CC -!- FUNCTION: Has antifungal activity against F.oxysporum, B.cinera and
CC M.arachidicola with IC(50) values of 1.4 uM, 2.5 uM and 0.15 uM,
CC respectively. Has antibacterial activity against the Gram-positive
CC bacteria B.megaterium, B.subtilis and M.phlei, and the Gram-negative
CC bacterium P.vulgaris. No antibacterial activity against the Gram-
CC positive bacteria B.cereus and S.aureus, or the Gram-negative bacteria
CC E.coli, E.aerogenes, P.aeruginosa and P.fluorescens. Has mitogenic
CC activity towards murine splenocytes. Inhibits the proliferation of M1
CC leukemia and MCF-7 breast cancer cells in vitro. Inhibits human
CC immunodeficiency virus-1 (HIV-1) reverse transcriptase.
CC {ECO:0000269|PubMed:15949629}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
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DR GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0045787; P:positive regulation of cell cycle; IDA:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0009615; P:response to virus; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Antiviral protein; Direct protein sequencing;
KW Fungicide; Mitogen; Plant defense.
FT PEPTIDE 1..10
FT /note="Defensin-like protein"
FT /id="PRO_0000244519"
FT NON_TER 10
FT /evidence="ECO:0000303|PubMed:15949629"
SQ SEQUENCE 10 AA; 1157 MW; 941D0DADD7244B1E CRC64;
KTCENLADTY