DEG1_CAEEL
ID DEG1_CAEEL Reviewed; 778 AA.
AC P24585;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Degenerin deg-1;
DE AltName: Full=Degeneration of certain neurons protein 1;
GN Name=deg-1; ORFNames=C47C12.6/C47C12.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=7627559; DOI=10.1016/s0960-9822(95)00085-6;
RA Garcia-Anoveros J., Ma C., Chalfie M.;
RT "Regulation of Caenorhabditis elegans degenerin proteins by a putative
RT extracellular domain.";
RL Curr. Biol. 5:441-448(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 485-778 (ISOFORM LONG).
RC STRAIN=Bristol N2;
RX PubMed=2342572; DOI=10.1038/345410a0;
RA Chalfie M., Wolinsky E.;
RT "The identification and suppression of inherited neurodegeneration in
RT Caenorhabditis elegans.";
RL Nature 345:410-416(1990).
CC -!- FUNCTION: Probable sodium channel subunit. Required by a subset of
CC neurons.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P24585-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P24585-2; Sequence=VSP_006198;
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000305}.
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DR EMBL; L34414; AAA99524.1; -; mRNA.
DR EMBL; FO080891; CCD67556.1; -; Genomic_DNA.
DR EMBL; X53314; CAA37396.1; -; mRNA.
DR PIR; T25652; T25652.
DR RefSeq; NP_509311.1; NM_076910.4. [P24585-1]
DR AlphaFoldDB; P24585; -.
DR STRING; 6239.C47C12.6.1; -.
DR TCDB; 1.A.6.2.1; the epithelial na(+) channel (enac) family.
DR EPD; P24585; -.
DR PaxDb; P24585; -.
DR PRIDE; P24585; -.
DR EnsemblMetazoa; C47C12.6a.1; C47C12.6a.1; WBGene00000950. [P24585-1]
DR EnsemblMetazoa; C47C12.6a.2; C47C12.6a.2; WBGene00000950. [P24585-1]
DR GeneID; 181035; -.
DR UCSC; C47C12.6.3; c. elegans. [P24585-1]
DR CTD; 181035; -.
DR WormBase; C47C12.6; CE24854; WBGene00000950; deg-1.
DR eggNOG; KOG4294; Eukaryota.
DR HOGENOM; CLU_017673_0_0_1; -.
DR InParanoid; P24585; -.
DR OMA; TPYCIGK; -.
DR OrthoDB; 686369at2759; -.
DR PhylomeDB; P24585; -.
DR PRO; PR:P24585; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000950; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; P24585; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0010447; P:response to acidic pH; IGI:WormBase.
DR GO; GO:0043200; P:response to amino acid; IMP:WormBase.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004726; Deg-1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690; PTHR11690; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR TIGRFAMs; TIGR00867; deg-1; 1.
DR PROSITE; PS01206; ASC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Neurodegeneration; Reference proteome; Sodium; Sodium channel;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..778
FT /note="Degenerin deg-1"
FT /id="PRO_0000181284"
FT TOPO_DOM 1..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..711
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 733..778
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 154..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 606
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 660..683
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_006198"
FT MUTAGEN 393
FT /note="A->T: In deg-1(u506); degeneration."
FT MUTAGEN 707
FT /note="A->V: In deg-1(u38) and deg-1(u529); degeneration."
FT MUTAGEN 710
FT /note="G->E: In deg-1(u512); prevents degeneration."
FT MUTAGEN 710
FT /note="G->R: In deg-1(u679); prevents degeneration."
FT MUTAGEN 720
FT /note="S->F: In deg-1(u558); prevents degeneration."
SQ SEQUENCE 778 AA; 88127 MW; 63390F537D0BAB05 CRC64;
MSNHHSKTKK TSMLGREDYI YSHDITNKNK KEKLNGASKN NDYNQDDDDE TMKSKMMDFC
DKTTAHGAKR VLIARNSFSK LMWGLIIFSF LLMFAYQASK LIFKFSAHEK ITDISLKFDD
VEFPAITFCN LNPYKKSLVM MVPSIRDTMD VYDNAKTHSK SEGEKKKPKV SRKQHSDASQ
QMVRELFAKE IEEGMVELKK SNKTLQSQNK SGRRRSQRSI ENRRYEAIEA HCKCVGNIGM
ECIRFESPPR DPSSKCICTY DRDMEVAWPC FNISVWYDHE CPLCHDDGYC ESTLPSGTTS
SDKWPCMCRN RGDTSERDDT PYCIGKAGVG KIEIRKLWLE NNMTTTSTTT TTTTTPPPTT
TSTTTTTTTT PPPTTTARPN QRAIVSNPET IKAMGFQGMT DGVAMLTRAK ENLMFTMAAL
SDKQRIALSQ SKHEFIEMCS FNGKECDIDE DFRLHVDPEF GNCFTFNYDV NNNYTSSRAG
PMYGIRVLLF VNTSDYMSTS ESSGVRLAIH PPTEYPFPDT FGYSAPVGFA SSFGIKKKVM
QRLPAPYGEC VETKKVVDRN YIYAGYDYHP EGCHRSCFQN GLIDDCSCGD PRFPVPEGYR
HCSAFNATAR TCLEKNIGSV GDFHHITQKM DKCVCKQSCE EIIHEVTFSC SKWPSGATDL
GDCDGMTESE CEQYYRLNAA MIEVFYEQLN YELLQESEAY GLVNLIADFG GHLGLWLGFS
VITVMEVCVL LVDMISLFFK SRHEEKLLRQ STKRKDVPED KRQITVGSGR KSDAFVSI
