DEGP3_ARATH
ID DEGP3_ARATH Reviewed; 559 AA.
AC Q9SHZ1; O04480;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Putative protease Do-like 3, mitochondrial;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=DEGP3; OrderedLocusNames=At1g65630; ORFNames=F1E22.1, F5I14.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11299370; DOI=10.1104/pp.125.4.1912;
RA Adam Z., Adamska I., Nakabayashi K., Ostersetzer O., Haussuhl K.,
RA Manuell A., Zheng B., Vallon O., Rodermel S.R., Shinozaki K., Clarke A.K.;
RT "Chloroplast and mitochondrial proteases in Arabidopsis. A proposed
RT nomenclature.";
RL Plant Physiol. 125:1912-1918(2001).
CC -!- FUNCTION: Putative serine protease.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60923.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC001229; AAB60923.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007234; AAF23847.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34405.1; -; Genomic_DNA.
DR RefSeq; NP_564856.1; NM_105236.2.
DR AlphaFoldDB; Q9SHZ1; -.
DR SMR; Q9SHZ1; -.
DR STRING; 3702.AT1G65630.1; -.
DR MEROPS; S01.A07; -.
DR PaxDb; Q9SHZ1; -.
DR PRIDE; Q9SHZ1; -.
DR EnsemblPlants; AT1G65630.1; AT1G65630.1; AT1G65630.
DR GeneID; 842874; -.
DR Gramene; AT1G65630.1; AT1G65630.1; AT1G65630.
DR KEGG; ath:AT1G65630; -.
DR Araport; AT1G65630; -.
DR TAIR; locus:2018476; AT1G65630.
DR eggNOG; KOG1320; Eukaryota.
DR HOGENOM; CLU_020120_10_0_1; -.
DR InParanoid; Q9SHZ1; -.
DR OMA; HEINHGY; -.
DR OrthoDB; 594175at2759; -.
DR PhylomeDB; Q9SHZ1; -.
DR PRO; PR:Q9SHZ1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHZ1; baseline and differential.
DR Genevisible; Q9SHZ1; AT.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR041517; DEGP_PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR Pfam; PF17815; PDZ_3; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
PE 3: Inferred from homology;
KW Hydrolase; Mitochondrion; Protease; Reference proteome; Serine protease;
KW Transit peptide.
FT TRANSIT 1..48
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 49..559
FT /note="Putative protease Do-like 3, mitochondrial"
FT /id="PRO_0000045831"
FT DOMAIN 300..380
FT /note="PDZ"
FT REGION 59..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..292
FT /note="Serine protease"
FT REGION 538..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 138
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 169
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 247
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 559 AA; 61712 MW; 58E41A590ED92757 CRC64;
MSFLCVRTVS RFRSLSRALA PGFLLLHGNA VPKTAVFFRQ QSSNTRLFSS YTAPSGVEEN
NSKSALKNKL PPGKEVSSKD AKEKITTSAI DLALNSVVKV FTVSSKPRLF QPWQITMQSE
STGSGFVISG KKILTNAHVV ANQTSVKVRK HGSTTKYKAK VQAVGHECDL AILEIDNDKF
WEGMNPLELG DIPSMQDTVY VVGYPKGGDT ISVSKGVVSR VGPIKYSHSG TELLAIQIDA
AINNGNSGGP VIMGNKVAGV AFESLCYSDS IGYIIPTPVI RHFLNAIEES GEDVSFGSIN
LTYQKMDNDQ LRKDFKMSDK MTGILINKIN PLSDVHKVLK KDDIILAIDG VPIGNDSSVH
FRKKERITFK HLVSMKKPCE TALLKVLREG KEYEFNSSLK SVPPLVPKRQ YDKSASYYIF
GGLVFLPLTK PYIDSSCVSE SALGKMPKKA GEQVVIISQI LEDDINTGYS IFEDFQVKKV
NGVQVHNLKH LYKLVEECCT ETVRMDLEKD KVITLDYKSA KKVTSKILKS LKIPSAVSED
LQPKQQNKRS KVPPKSKEH
