ID   DEGP7_ARATH             Reviewed;        1097 AA.
AC   Q8RY22; Q9SRP2; Q9SRP3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protease Do-like 7;
DE            EC=3.4.21.-;
GN   Name=DEGP7; OrderedLocusNames=At3g03380; ORFNames=T21P5.19, T21P5.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11299370; DOI=10.1104/pp.125.4.1912;
RA   Adam Z., Adamska I., Nakabayashi K., Ostersetzer O., Haussuhl K.,
RA   Manuell A., Zheng B., Vallon O., Rodermel S.R., Shinozaki K., Clarke A.K.;
RT   "Chloroplast and mitochondrial proteases in Arabidopsis. A proposed
RT   nomenclature.";
RL   Plant Physiol. 125:1912-1918(2001).
CC   -!- FUNCTION: Probable serine protease.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved Asp residue in position 654 essential for
CC       protease activity. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF01593.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF01594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC009895; AAF01593.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC009895; AAF01594.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE73938.1; -; Genomic_DNA.
DR   EMBL; AY078951; AAL84951.1; -; mRNA.
DR   EMBL; BT002727; AAO11643.1; -; mRNA.
DR   RefSeq; NP_566204.2; NM_111209.3.
DR   AlphaFoldDB; Q8RY22; -.
DR   SMR; Q8RY22; -.
DR   BioGRID; 6601; 4.
DR   STRING; 3702.AT3G03380.1; -.
DR   iPTMnet; Q8RY22; -.
DR   PaxDb; Q8RY22; -.
DR   PRIDE; Q8RY22; -.
DR   ProteomicsDB; 222204; -.
DR   EnsemblPlants; AT3G03380.1; AT3G03380.1; AT3G03380.
DR   GeneID; 821268; -.
DR   Gramene; AT3G03380.1; AT3G03380.1; AT3G03380.
DR   KEGG; ath:AT3G03380; -.
DR   Araport; AT3G03380; -.
DR   TAIR; locus:2099619; AT3G03380.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_1_1_1; -.
DR   InParanoid; Q8RY22; -.
DR   OrthoDB; 93889at2759; -.
DR   PhylomeDB; Q8RY22; -.
DR   PRO; PR:Q8RY22; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8RY22; baseline and differential.
DR   Genevisible; Q8RY22; AT.
DR   GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR   GO; GO:0008233; F:peptidase activity; IDA:TAIR.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0010205; P:photoinhibition; IMP:TAIR.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13180; PDZ_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Protease; Reference proteome; Serine protease.
FT   CHAIN           1..1097
FT                   /note="Protease Do-like 7"
FT                   /id="PRO_0000093862"
FT   DOMAIN          269..366
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          55..243
FT                   /note="Serine protease"
FT   REGION          546..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        524
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        785
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1097 AA;  119877 MW;  F3C42D4FAAD31859 CRC64;
     MGDPLERLGS QASMATESVM KEDLCLEIDP PLTESVATAE DWRRALGKVV PAVVVLRTTA
     CRAFDTESAG ASYATGFIVD KRRGIILTNR HVVKPGPVVA EAMFVNREEI PIYPVYRDPV
     HDFGFFCYDP SAVQFLTYQE IPLAPEAASV GLEIRVVGND SGEKVSILAG TLARLDRDAP
     HYKKDGYNDF NTFYMQAASG TKGGSSGSPV IDWQGRAVAL NAGSKSSSAS AFFLPLQRVV
     RALSFLQKSI DSRTDKPKAV HIPRGTLQMT FLHKGFDEIR RLGLRSETEQ VVRHASPTGE
     TGMLVVDSVV PSGPADKHLE PGDVLVRVNG TVLTQFLNLE NLLDDGVGQI LELEIERGGQ
     PLSVSVSVQD LHSITPDHFL EVSGAVIHPL SYQQARNFRF PCGLAYVADP GYMLFRAGVP
     RHAIIKKVAN EDISSLGDLV SVLSKLSRGA RVPLEYMSHT DRHRKKSVLV TIDHHEWYAP
     PQLYTRNDSS GLWDAKPAIE PASVSPSIGN NGFPISQDIS LCHHDTEPMH EVNVRGVTDI
     AAIMETSSGD GSQNDFGSEA KKQRVDEDSS DGIAANGSLY GSEFKSDDAM ETDTTVLRDF
     EGATALSANA SLAERAIEPA LVMFEVHVPP SCSLDGVHSQ HFFGTGIIIY HSSNMGLAVV
     DKNTVAISAS DVMLSFAAFP VEIPGEVVFL HPVHNYALIA YNPSAMDPAS ASVIRAAELL
     PEPALQRGDS VYLVGLSRNL QATSRKSIVT NPCAALNIGS ADSPRYRATN MEVIELDTDF
     GSSFSGALTD EQGRIRAIWG SFSTQVKYSS TSSEDHQFVR GIPVYAISQV LEKIITGGNG
     PALLINGVKR PMPLVRILEV ELYPTLLSKA RSFGLSDEWI QVLVKKDPVR RQVLRVKGCL
     AGSKAENLLE QGDMVLAVNK MPVTCFNDIE AACQTLDKGS YSDENLNLTI LRQGQELELV
     VGTDKRDGNG TTRVINWCGC VVQDPHPAVR ALGFLPEEGH GVYVTRWCHG SPAHRYGLYA
     LQWIVEVNGK KTPDLNAFAD ATKELEHGQF VRIRTVHLNG KPRVLTLKQD LHYWPTWELR
     FDPETALWRR NILKALQ