ID   DEGR_BACSU              Reviewed;          60 AA.
AC   P68731; P06563;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Regulatory protein DegR;
GN   Name=degR; Synonyms=prtR; OrderedLocusNames=BSU21940;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / PY79;
RX   PubMed=3098734; DOI=10.1128/jb.169.1.434-437.1987;
RA   Yang M., Shimotsu H., Ferrari E., Henner D.J.;
RT   "Characterization and mapping of the Bacillus subtilis prtR gene.";
RL   J. Bacteriol. 169:434-437(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8969496; DOI=10.1099/13500872-142-11-3005;
RA   Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.;
RT   "Organization of the Bacillus subtilis 168 chromosome between kdg and the
RT   attachment site of the SP beta prophage: use of long accurate PCR and yeast
RT   artificial chromosomes for sequencing.";
RL   Microbiology 142:3005-3015(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   PROTEIN SEQUENCE OF 1-20, FUNCTION, AND SUBUNIT.
RX   PubMed=1459944; DOI=10.1128/jb.174.24.7954-7962.1992;
RA   Mukai K., Kawata-Mukai M., Tanaka T.;
RT   "Stabilization of phosphorylated Bacillus subtilis DegU by DegR.";
RL   J. Bacteriol. 174:7954-7962(1992).
RN   [5]
RP   INDUCTION.
RX   PubMed=8550420; DOI=10.1128/jb.178.1.216-222.1996;
RA   Ogura M., Tanaka T.;
RT   "Transcription of Bacillus subtilis degR is sigma D dependent and
RT   suppressed by multicopy proB through sigma D.";
RL   J. Bacteriol. 178:216-222(1996).
RN   [6]
RP   INDUCTION.
RX   PubMed=9108277; DOI=10.1007/s004380050403;
RA   Ogura M., Tanaka T.;
RT   "Bacillus subtilis ComK negatively regulates degR gene expression.";
RL   Mol. Gen. Genet. 254:157-165(1997).
CC   -!- FUNCTION: Stabilizes the phosphorylated form of DegU, leading to
CC       enhanced production of levansucrase, alkaline protease, and neutral
CC       protease. {ECO:0000269|PubMed:1459944}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000305|PubMed:1459944}.
CC   -!- INDUCTION: Expression is sigma D-dependent. Negatively regulated by
CC       ComK. {ECO:0000269|PubMed:8550420, ECO:0000269|PubMed:9108277}.
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DR   EMBL; M15318; AAA22672.1; -; Genomic_DNA.
DR   EMBL; L77246; AAA96622.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14112.1; -; Genomic_DNA.
DR   PIR; I39957; I39957.
DR   RefSeq; NP_390077.1; NC_000964.3.
DR   RefSeq; WP_003230774.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P68731; -.
DR   SMR; P68731; -.
DR   STRING; 224308.BSU21940; -.
DR   PaxDb; P68731; -.
DR   PRIDE; P68731; -.
DR   EnsemblBacteria; CAB14112; CAB14112; BSU_21940.
DR   GeneID; 939076; -.
DR   KEGG; bsu:BSU21940; -.
DR   PATRIC; fig|224308.179.peg.2396; -.
DR   OMA; CKQNLVA; -.
DR   BioCyc; BSUB:BSU21940-MON; -.
DR   Proteomes; UP000001570; Chromosome.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..60
FT                   /note="Regulatory protein DegR"
FT                   /id="PRO_0000079857"
SQ   SEQUENCE   60 AA;  7109 MW;  C7B7F892FF0AB131 CRC64;
     MDDKDLKLIL HKTFIEIYSD LEELADIAKK GKPSMEKYVE EIEQRCKQNI LAIEIQMKIK