ID   DEGT_GEOSE              Reviewed;         372 AA.
AC   P15263;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Pleiotropic regulatory protein;
GN   Name=degT;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29609 / DSM 2027 / NCA 1503 / NCIMB 8924;
RX   PubMed=2104607; DOI=10.1128/jb.172.1.411-418.1990;
RA   Takagi M., Takada H., Imanaka T.;
RT   "Nucleotide sequence and cloning in Bacillus subtilis of the Bacillus
RT   stearothermophilus pleiotropic regulatory gene degT.";
RL   J. Bacteriol. 172:411-418(1990).
CC   -!- FUNCTION: This membrane protein may function as a sensor protein and
CC       may transfer the signal of environmental stimuli to the regulatory
CC       region of target genes to activate or repress transcription of the
CC       genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DegT/DnrJ/EryC1 family. {ECO:0000305}.
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DR   EMBL; M29002; AAA22387.1; -; Genomic_DNA.
DR   PIR; I39836; I39836.
DR   RefSeq; WP_033014895.1; NZ_RCTK01000027.1.
DR   AlphaFoldDB; P15263; -.
DR   SMR; P15263; -.
DR   GeneID; 58573852; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd00616; AHBA_syn; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR000653; DegT/StrS_aminotransferase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR30244; PTHR30244; 1.
DR   Pfam; PF01041; DegT_DnrJ_EryC1; 1.
DR   PIRSF; PIRSF000390; PLP_StrS; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
KW   Cell membrane; DNA-binding; Membrane; Pyridoxal phosphate; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..372
FT                   /note="Pleiotropic regulatory protein"
FT                   /id="PRO_0000110010"
FT   DNA_BIND        160..179
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          53..158
FT                   /note="Hydrophobic"
FT   MOD_RES         186
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   372 AA;  41246 MW;  0D017E67F1088161 CRC64;
     MNVPMLDLSE QYEQLKPEIM RVLDEVMRSS RFILGDYVKK LEADIAAYSR AKHGIGCGNG
     SDAIHIALQA AGVGPGDEVI TTAFTFFATA GSIARAGAKP VFVDIDPVTF NIDPAQVEAA
     VTEKTKAIIP VHLYGQMADM EAIAAIAKRH GLVVIEDAAQ AIGAKYNGKC VGELGTAATY
     SFFPTKNLGA YGDGGMIITN DDELAEKCRV IRVHGSKPKY YHHVLGYNSR LDEMQAAILS
     VKFPHLDRWT EQRRKHAATY TRLLEEAVGD LVVTPKEVDG RYHVFHQYTI RAPKRDELQA
     FLKEQGIATM VYYPLPLHLQ PVFASLGYKE GQLPEAEKAA KEALSLPMFP ELKEEQQQYV
     VEKIAEFYRH FA