ID   DEGU_BREBE              Reviewed;         236 AA.
AC   P54662;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Transcriptional regulatory protein DegU;
GN   Name=degU;
OS   Brevibacillus brevis (Bacillus brevis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=1393;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Alk36;
RX   PubMed=7765823; DOI=10.1007/bf00170228;
RA   Louw M.E., Reid S.J., James M.D., Watson T.G.;
RT   "Cloning and sequencing the degS-degU operon from an alkalophilic Bacillus
RT   brevis.";
RL   Appl. Microbiol. Biotechnol. 42:78-84(1994).
CC   -!- FUNCTION: Member of the two-component regulatory system DegS/DegU,
CC       which plays an important role in the transition growth phase.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated and dephosphorylated by DegS. {ECO:0000250}.
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DR   EMBL; L15444; AAC41439.1; -; Genomic_DNA.
DR   PIR; I39835; I39835.
DR   AlphaFoldDB; P54662; -.
DR   SMR; P54662; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Repressor;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..236
FT                   /note="Transcriptional regulatory protein DegU"
FT                   /id="PRO_0000081098"
FT   DOMAIN          11..127
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          166..231
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        190..209
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         62
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   236 AA;  27003 MW;  9E464265B0363315 CRC64;
     MNEQVNENKI QIVIIDDHQL FREGVKRILA MEPEFEVVAD GEDGENAVEL VEKYNPDVIL
     MDINMPKVNG VEATRDLIQR YPDVKVLVLS IHDDESYVTH VLKTGASGYL LKEMDADALI
     EAVKVVAQGG AYIHPKVTHN LIKEYRRLVN EDEQESSEIG FKEVEYRKPL HILTRRECEV
     LQLMTDGYSN RMIGEALYIS EKTVKNHVSN ILQKMNVNDR TQAVVESIKN GWVKVR