ID   DEL1_CAEEL              Reviewed;         664 AA.
AC   Q19038;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Degenerin del-1;
GN   Name=del-1; ORFNames=E02H4.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RA   Tavernarakis N., Shreffler W., Wang S.L., Driscoll M.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable sodium channel subunit.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000305}.
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DR   EMBL; U76403; AAB39735.1; -; mRNA.
DR   EMBL; Z68003; CAA91975.1; -; Genomic_DNA.
DR   PIR; T20420; T20420.
DR   RefSeq; NP_510380.1; NM_077979.1.
DR   AlphaFoldDB; Q19038; -.
DR   STRING; 6239.E02H4.1; -.
DR   TCDB; 1.A.6.2.5; the epithelial na(+) channel (enac) family.
DR   PaxDb; Q19038; -.
DR   EnsemblMetazoa; E02H4.1a.1; E02H4.1a.1; WBGene00000952.
DR   UCSC; E02H4.1; c. elegans.
DR   WormBase; E02H4.1a; CE52816; WBGene00000952; del-1.
DR   eggNOG; KOG4294; Eukaryota.
DR   HOGENOM; CLU_017673_0_0_1; -.
DR   InParanoid; Q19038; -.
DR   OMA; NACICNY; -.
DR   OrthoDB; 686369at2759; -.
DR   PhylomeDB; Q19038; -.
DR   PRO; PR:Q19038; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000952; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; Q19038; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; PTHR11690; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   TIGRFAMs; TIGR00867; deg-1; 1.
DR   PROSITE; PS01206; ASC; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium channel; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..664
FT                   /note="Degenerin del-1"
FT                   /id="PRO_0000181285"
FT   TOPO_DOM        1..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..607
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        608..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        629..664
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        241
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        394
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        508
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        562
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   664 AA;  75474 MW;  0D19C8EF79688F8D CRC64;
     MARKYIDILK KSKMMLFQDV GKSFEDDSPC KEEAPKTQIQ HSVRDFCEQT TFHGVNMIFT
     TSLYWVRFLW VVVSLVCICL CMYSFSHVKD KYDRKEKIVN VELVFESAPF PAITVCNLNP
     FKNHLARSVP EISETLDAFH QAVVYSNDAT MDELSGRGRR SLNDGPSFKY LQYEPVYSDC
     SCVPGRQECI AQTSAPRTLE NACICNYDRH DGSAWPCYSA QTWEKSICPE CNDIGFCNVP
     NTTGSGNIPC YCQLEMGYCV FQPESRVRRI WEFQGNKIPE KGSPLRKEYM EQLTQLGYGN
     MTDQVAITTQ AKEKMILKMS GLHPQRRAAL GYGKSELIKM CSFNGQQCNI DTEFKLHIDP
     SFGNCYTFNA NPEKKLASSR AGPSYGLRLM MFVNSSDYLP TTEATGVRIA IHGKEECPFP
     DTFGYSAPTG VISSFGISLR NINRLPQPYG NCLQKDNPQS RSIYKGYKYE PEGCFRSCYQ
     YRIIAKCGCA DPRYPKPWKR SAWCDSTNTT TLNCLTTEGA KLSTKENQKH CKCIQPCQQD
     QYTTTYSAAK WPSGSIQTSC DNHSKDCNSY LREHAAMIEI YYEQMSYEIL RESESYSWFN
     LMADMGGQAG LFLGASIMSV IEFLFFAVRT LGIACKPRRW RQKTELLRAE ELNDAEKGVS
     TNNN