ID   DEM_PITHY               Reviewed;           7 AA.
AC   P84523;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   02-DEC-2020, entry version 25.
DE   RecName: Full=Dermorphin {ECO:0000303|Ref.1};
DE   AltName: Full=Hyp-6 {ECO:0000303|Ref.1};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, HYDROXYLATION AT PRO-6, AMIDATION AT SER-7, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RA   Thompson A.H.;
RT   "Bioactive peptides derived from the venom of the South American tree frog,
RT   Phyllomedusa hypochondrialis.";
RL   Submitted (APR-2005) to UniProtKB.
CC   -!- FUNCTION: Dermorphin has a very potent opiate-like activity. It has
CC       high affinity and selectivity for mu-type opioid receptors (By
CC       similarity). {ECO:0000250|UniProtKB:P05422}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermorphin subfamily. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing; Endorphin;
KW   Hydroxylation; Opioid peptide; Secreted.
FT   PEPTIDE         1..7
FT                   /note="Dermorphin"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000043783"
FT   MOD_RES         6
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         7
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   7 AA;  804 MW;  75A77B5879CDCB30 CRC64;
     YAFGYPS