ID   DEN10_DANRE             Reviewed;         349 AA.
AC   A8E7G4; A8WFY8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DENN domain-containing protein 10 {ECO:0000305};
DE   AltName: Full=Protein FAM45;
DE   AltName: Full=Protein FAM45A;
GN   Name=dennd10; Synonyms=fam45, fam45a; ORFNames=si:ch211-117n7.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-349.
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) which may be
CC       involved in the regulation of late endocytic pathway homeostasis,
CC       including endosomal positioning, maturation and secretion.
CC       {ECO:0000250|UniProtKB:Q8TCE6}.
CC   -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q8TCE6}.
CC   -!- SIMILARITY: Belongs to the DENND10 family. {ECO:0000305}.
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DR   EMBL; BX248127; CAP09408.1; -; Genomic_DNA.
DR   EMBL; BC154508; AAI54509.1; -; mRNA.
DR   RefSeq; NP_001161133.1; NM_001167661.1.
DR   RefSeq; XP_684048.3; XM_678956.8.
DR   AlphaFoldDB; A8E7G4; -.
DR   SMR; A8E7G4; -.
DR   STRING; 7955.ENSDARP00000086028; -.
DR   PaxDb; A8E7G4; -.
DR   Ensembl; ENSDART00000091595; ENSDARP00000086028; ENSDARG00000062965.
DR   GeneID; 556203; -.
DR   KEGG; dre:556203; -.
DR   CTD; 404636; -.
DR   ZFIN; ZDB-GENE-030131-3548; dennd10.
DR   eggNOG; ENOG502QVHR; Eukaryota.
DR   GeneTree; ENSGT00940000164222; -.
DR   InParanoid; A8E7G4; -.
DR   OMA; VKMMEAY; -.
DR   OrthoDB; 1065142at2759; -.
DR   PhylomeDB; A8E7G4; -.
DR   TreeFam; TF332501; -.
DR   PRO; PR:A8E7G4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000062965; Expressed in intestine and 19 other tissues.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   GO; GO:2000641; P:regulation of early endosome to late endosome transport; ISS:UniProtKB.
DR   InterPro; IPR042431; FAM45.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR28544; PTHR28544; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..349
FT                   /note="DENN domain-containing protein 10"
FT                   /id="PRO_0000387948"
FT   DOMAIN          1..135
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          160..294
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          296..349
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
SQ   SEQUENCE   349 AA;  39662 MW;  102AB1CC9C50E98E CRC64;
     MATPELMLSL GLIEKDVNAD TLWVWCYPSI DADLREVMLR KCCLTLDNQV LHTFVFGQFC
     RTWYYITTVE VQEPTVLKKV THFSIVVTAK DFNPEKYAAF SRVLCRTYMK HGSPVKMMEG
     YIAVLTKGIC QSDENGSFLI KDYDVRKALL AGSLKDVVSQ FGMETIILYT ALMLKKRVVV
     YHPRIEALLE FTRALPCLVW HRKDWSILHP FVHLENDELE NLKVCTGYVA GFVDPEVKDR
     SDLFDVFVNL PDSEITVSQN AKEAMSMGKL HKEIGNFIVQ AAEDADRSDA QVIKDISVKT
     KEILSNLMSL ADHADNSKLT LECLKQGHYP PATENFLFHL AAAEQLLKI