ID   DEN10_DICDI             Reviewed;         366 AA.
AC   Q55FE3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=DENN domain-containing protein 10 {ECO:0000305};
DE   AltName: Full=Protein FAM45 homolog;
GN   Name=dennd10; Synonyms=fam45; ORFNames=DDB_G0268448;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16507593; DOI=10.1242/jcs.02819;
RA   Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA   Calvo R.M., Escalante R.;
RT   "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT   required for mitochondrial function and development.";
RL   J. Cell Sci. 119:1154-1164(2006).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) which may be
CC       involved in the regulation of homeostasis of late endocytic pathway,
CC       including endosomal positioning, maturation and secretion.
CC       {ECO:0000250|UniProtKB:Q8TCE6}.
CC   -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q8TCE6}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16507593}.
CC   -!- SIMILARITY: Belongs to the DENND10 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73677.1; -; Genomic_DNA.
DR   RefSeq; XP_647590.1; XM_642498.1.
DR   AlphaFoldDB; Q55FE3; -.
DR   STRING; 44689.DDB0232143; -.
DR   PaxDb; Q55FE3; -.
DR   EnsemblProtists; EAL73677; EAL73677; DDB_G0268448.
DR   GeneID; 8616402; -.
DR   KEGG; ddi:DDB_G0268448; -.
DR   dictyBase; DDB_G0268448; fam45.
DR   eggNOG; ENOG502QVHR; Eukaryota.
DR   HOGENOM; CLU_050301_0_0_1; -.
DR   InParanoid; Q55FE3; -.
DR   OMA; VKMMEAY; -.
DR   PhylomeDB; Q55FE3; -.
DR   PRO; PR:Q55FE3; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:2000641; P:regulation of early endosome to late endosome transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR042431; FAM45.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR28544; PTHR28544; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Endosome; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..366
FT                   /note="DENN domain-containing protein 10"
FT                   /id="PRO_0000327868"
FT   DOMAIN          1..147
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          169..309
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          311..366
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
SQ   SEQUENCE   366 AA;  41594 MW;  E09C7D5ADF774EC9 CRC64;
     MATSISLEDS ITIFEKDQNS DVLMSWCFPT ITEDLKSVIL NRTSLLQEKI SLQFSFSKFK
     NSWIYIYTTS VETQQINKED GSITQINVPD SLKRVVAFSL VLVRNQFNPE KYGSLAQIMS
     SVYKQTGDCS KLLECQLRVF NRGQFDVGSM GKFVDSSFDV RRSYLQTSIK DIIQLFGEEI
     ILIWSAMAMK KRIVVYSEKL SSLLKVIRAL PLFVFHRQNW NILRPFVTIS DLELKDLVST
     GVYCAGFTDS SIKSREDLYD ILVDLSSKEV SVSSQSKDQF ILGSFHKDVL RFLLDSLDDE
     EITDQNVIKG LNLKMKELLT KLESLKETNE ETGKSSITLE SLETRKLPNG MSTFLFNIAN
     AEGLNG