DEN11_DANRE
ID DEN11_DANRE Reviewed; 490 AA.
AC Q1LX49;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=DENN domain-containing protein 11 {ECO:0000305};
DE Short=DENND11;
DE AltName: Full=Protein LCHN;
GN Name=dennd11; Synonyms=lchn; ORFNames=si:ch211-238n5.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF). May
CC promote the exchange of GDP to GTP, converting inactive GDP-bound small
CC GTPases into their active GTP-bound form. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DENND11 family. {ECO:0000305}.
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DR EMBL; BX470166; CAK04663.1; -; Genomic_DNA.
DR RefSeq; NP_001037812.1; NM_001044347.1.
DR AlphaFoldDB; Q1LX49; -.
DR STRING; 7955.ENSDARP00000084619; -.
DR PaxDb; Q1LX49; -.
DR Ensembl; ENSDART00000141367; ENSDARP00000120653; ENSDARG00000062381.
DR GeneID; 556432; -.
DR KEGG; dre:556432; -.
DR CTD; 57189; -.
DR ZFIN; ZDB-GENE-050419-80; dennd11.
DR eggNOG; KOG4704; Eukaryota.
DR GeneTree; ENSGT00590000083189; -.
DR HOGENOM; CLU_049607_0_0_1; -.
DR InParanoid; Q1LX49; -.
DR OMA; TGNMVEW; -.
DR OrthoDB; 1439536at2759; -.
DR PhylomeDB; Q1LX49; -.
DR PRO; PR:Q1LX49; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000062381; Expressed in granulocyte and 21 other tissues.
DR ExpressionAtlas; Q1LX49; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR018626; LCHN/Anr2.
DR InterPro; IPR037516; Tripartite_DENN.
DR Pfam; PF09804; DENND11; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..490
FT /note="DENN domain-containing protein 11"
FT /id="PRO_0000315224"
FT DOMAIN 19..221
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 249..397
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 399..490
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54831 MW; 49720374F1AD20DF CRC64;
MVEQSDRAPL LDWEEIPPAE LAPSVPSPDT GDSLQSGLSS YPTEATLGAD ITLNTSPTRP
SSVAAVHSPH KQHSGPGGDA LAEEDEPGDC AFHGLSVRDR RITGWEEKDQ IVAVFVVTFD
TRSGNMIEWC LPHDVNLEGV EFKSMASGSH RISSDFIYFR KGCYFGLACF ANMPVESELE
RGARMKSVGI LSPSYTLLYR YMHFLENQVR HQLQCPGQYS PLEAFYEDKK AVLPSGGNGL
VTACPTSALA PIVNRCMHPE MKITHPAGCM SQFIRFFGEQ IMVLWKFALL RKRILIFSPP
PVGVVCYRVY CCCCLANVSI PGMGVSVPEF RPFFYINVAD IPALETELSY VACTTEKIFE
EKKELYDVYI DNQNVKTHRE SLQPLLRLNS ADREKYRKLC EQRQLLLYSQ EVDGDCTSNE
EDLFILFFME QNNRIFQTLS EVAVSADPTL TAEHVRAMGL DPQGDRGFLV DLLEIYGIDV
MLVIDNPCCP
