DEN11_MOUSE
ID DEN11_MOUSE Reviewed; 455 AA.
AC Q3UHG7; Q3UT59; Q80TI8; Q8C6M2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=DENN domain-containing protein 11 {ECO:0000305};
DE Short=DENND11;
DE AltName: Full=Protein LCHN;
GN Name=Dennd11; Synonyms=Kiaa1147, Lchn {ECO:0000250|UniProtKB:Q0PGW2};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Egg, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-455 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF). May
CC promote the exchange of GDP to GTP, converting inactive GDP-bound small
CC GTPases into their active GTP-bound form (Probable). May play a role in
CC neuritogenesis, as well as in neuronal recovery and/or restructuring in
CC the hippocampus following transient cerebral ischemia (By similarity).
CC {ECO:0000250|UniProtKB:Q0PGW2, ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UHG7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UHG7-2; Sequence=VSP_030494;
CC -!- SIMILARITY: Belongs to the DENND11 family. {ECO:0000305}.
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DR EMBL; AK122457; BAC65739.1; -; mRNA.
DR EMBL; AK054277; BAC35714.1; -; mRNA.
DR EMBL; AK139744; BAE24121.1; -; mRNA.
DR EMBL; AK147402; BAE27890.1; -; mRNA.
DR CCDS; CCDS90040.1; -. [Q3UHG7-1]
DR RefSeq; NP_780737.1; NM_175528.4.
DR AlphaFoldDB; Q3UHG7; -.
DR STRING; 10090.ENSMUSP00000045103; -.
DR iPTMnet; Q3UHG7; -.
DR PhosphoSitePlus; Q3UHG7; -.
DR EPD; Q3UHG7; -.
DR MaxQB; Q3UHG7; -.
DR PaxDb; Q3UHG7; -.
DR PeptideAtlas; Q3UHG7; -.
DR PRIDE; Q3UHG7; -.
DR ProteomicsDB; 264728; -. [Q3UHG7-1]
DR ProteomicsDB; 264729; -. [Q3UHG7-2]
DR Antibodypedia; 50001; 32 antibodies from 11 providers.
DR Ensembl; ENSMUST00000039008; ENSMUSP00000045103; ENSMUSG00000037172. [Q3UHG7-2]
DR Ensembl; ENSMUST00000101492; ENSMUSP00000099031; ENSMUSG00000037172. [Q3UHG7-1]
DR UCSC; uc009bmo.1; mouse. [Q3UHG7-1]
DR MGI; MGI:2444256; Dennd11.
DR VEuPathDB; HostDB:ENSMUSG00000037172; -.
DR eggNOG; KOG4704; Eukaryota.
DR GeneTree; ENSGT00590000083189; -.
DR HOGENOM; CLU_049607_0_0_1; -.
DR InParanoid; Q3UHG7; -.
DR OMA; TGNMVEW; -.
DR OrthoDB; 1439536at2759; -.
DR PhylomeDB; Q3UHG7; -.
DR TreeFam; TF329174; -.
DR BioGRID-ORCS; 243780; 2 hits in 57 CRISPR screens.
DR ChiTaRS; E330009J07Rik; mouse.
DR PRO; PR:Q3UHG7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q3UHG7; protein.
DR Bgee; ENSMUSG00000037172; Expressed in lacrimal gland and 247 other tissues.
DR ExpressionAtlas; Q3UHG7; baseline and differential.
DR Genevisible; Q3UHG7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR018626; LCHN/Anr2.
DR InterPro; IPR037516; Tripartite_DENN.
DR Pfam; PF09804; DENND11; 1.
DR PROSITE; PS50211; DENN; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Guanine-nucleotide releasing factor;
KW Methylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:A4D1U4"
FT CHAIN 2..455
FT /note="DENN domain-containing protein 11"
FT /id="PRO_0000315222"
FT DOMAIN 15..187
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 214..362
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 364..455
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylvaline"
FT /evidence="ECO:0000250|UniProtKB:A4D1U4"
FT MOD_RES 41
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:A4D1U4"
FT VAR_SEQ 392..455
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030494"
SQ SEQUENCE 455 AA; 51428 MW; 7CC18AB0A2B970D1 CRC64;
MVEQGDAAPL LRWAEGPAVS VPQDPALQAG GWVRGGSGEG RVAAEAPRRR EPDEPAPPEV
LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD IDLEGVEFKS MASGSHKVQS
DFIYFRKGPF FGLACFANMP VESELERGAR MKSVGILSPS YTLLYRYMHF LENQVRHQLE
MPGHYSHLAA FYEDKKGVLH AGPGRGGSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK
FFGEQILILW KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL LKINSADREK
YRRLNEQRQM LLYSQEVEGD YSPCEEDLFV LFFLEQNNRI FQTLLEVSAS QDKTLTAEHA
RGMGLDPQGD RSFLMDLLEA YGIDVMLVID NPCCP
