ID   DEN11_RAT               Reviewed;         455 AA.
AC   Q0PGW2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DENN domain-containing protein 11 {ECO:0000305};
DE            Short=DENND11;
DE   AltName: Full=Protein LCHN {ECO:0000303|PubMed:17394467};
GN   Name=Dennd11; Synonyms=Lchn {ECO:0000303|PubMed:17394467};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar;
RX   PubMed=17394467; DOI=10.1111/j.1471-4159.2006.04374.x;
RA   Zhang G., Jung B.P., Ho W., Jugloff D.G.M., Cheung H.H., Gurd J.W.,
RA   Wallace M.C., Eubanks J.H.;
RT   "Isolation and characterization of LCHN: a novel factor induced by
RT   transient global ischemia in the adult rat hippocampus.";
RL   J. Neurochem. 101:263-273(2007).
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF). May
CC       promote the exchange of GDP to GTP, converting inactive GDP-bound small
CC       GTPases into their active GTP-bound form (Probable). May play a role in
CC       neuritogenesis, as well as in neuronal recovery and/or restructuring in
CC       the hippocampus following transient cerebral ischemia.
CC       {ECO:0000269|PubMed:17394467, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed within the somatodendritic compartment of
CC       neurons, is also present on dendritic growth cones, but is not found in
CC       astrocytes. {ECO:0000269|PubMed:17394467}.
CC   -!- INDUCTION: By transient cerebral ischemia.
CC       {ECO:0000269|PubMed:17394467}.
CC   -!- SIMILARITY: Belongs to the DENND11 family. {ECO:0000305}.
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DR   EMBL; DQ836251; ABH04324.1; -; mRNA.
DR   RefSeq; NP_001038166.1; NM_001044701.1.
DR   RefSeq; XP_006236423.2; XM_006236361.3.
DR   AlphaFoldDB; Q0PGW2; -.
DR   STRING; 10116.ENSRNOP00000015921; -.
DR   SwissPalm; Q0PGW2; -.
DR   jPOST; Q0PGW2; -.
DR   PaxDb; Q0PGW2; -.
DR   Ensembl; ENSRNOT00000015921; ENSRNOP00000015921; ENSRNOG00000011854.
DR   GeneID; 312270; -.
DR   KEGG; rno:312270; -.
DR   UCSC; RGD:1563986; rat.
DR   CTD; 57189; -.
DR   RGD; 1563986; RGD1563986.
DR   eggNOG; KOG4704; Eukaryota.
DR   GeneTree; ENSGT00590000083189; -.
DR   HOGENOM; CLU_049607_0_0_1; -.
DR   InParanoid; Q0PGW2; -.
DR   OMA; TGNMVEW; -.
DR   OrthoDB; 1439536at2759; -.
DR   PhylomeDB; Q0PGW2; -.
DR   TreeFam; TF329174; -.
DR   PRO; PR:Q0PGW2; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000011854; Expressed in cerebellum and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018626; LCHN/Anr2.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   Pfam; PF09804; DENND11; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Guanine-nucleotide releasing factor; Methylation;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:A4D1U4"
FT   CHAIN           2..455
FT                   /note="DENN domain-containing protein 11"
FT                   /id="PRO_0000315223"
FT   DOMAIN          15..187
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          214..362
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          364..455
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   REGION          21..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylvaline"
FT                   /evidence="ECO:0000250|UniProtKB:A4D1U4"
FT   MOD_RES         41
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A4D1U4"
SQ   SEQUENCE   455 AA;  51370 MW;  C99B6E05D1079436 CRC64;
     MVEQGDAAPL LRWAEGPAVS VPQDPALQAG GWVRGGSGGG RVAAEAPRRR EPEEPAPPEV
     LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD IDLEGVEFKS MASGSHKVQS
     DFIYFRKGPF FGLACFANMP VESELERGAR MKSVGILSPS YTLLYRYMHF LENQVRHQLE
     MPGHYSHLAA FYEDKKGVLH AGPGRGGSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK
     FFGEQILILW KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
     VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL LKLNSADREK
     YRRLNEQRQM LLYSQEVEGD YSPCEEDLFV LFFLEQNNRI FQTLLEVSAS QDKTLTAEHA
     RGMGLDPQGD RSFLMDLLEA YGIDVMLVID NPCCP