ID   DEN11_XENLA             Reviewed;         434 AA.
AC   Q4FZX0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=DENN domain-containing protein 11 {ECO:0000305};
DE            Short=DENND11;
DE   AltName: Full=Protein LCHN;
GN   Name=dennd11; Synonyms=lchn;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF). May
CC       promote the exchange of GDP to GTP, converting inactive GDP-bound small
CC       GTPases into their active GTP-bound form. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DENND11 family. {ECO:0000305}.
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DR   EMBL; BC098994; AAH98994.1; -; mRNA.
DR   RefSeq; NP_001089578.1; NM_001096109.1.
DR   AlphaFoldDB; Q4FZX0; -.
DR   DNASU; 734634; -.
DR   GeneID; 734634; -.
DR   KEGG; xla:734634; -.
DR   CTD; 734634; -.
DR   Xenbase; XB-GENE-6255585; dennd11.L.
DR   OrthoDB; 1439536at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734634; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018626; LCHN/Anr2.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   Pfam; PF09804; DENND11; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..434
FT                   /note="DENN domain-containing protein 11"
FT                   /id="PRO_0000315225"
FT   DOMAIN          1..168
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          194..341
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          343..434
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  49450 MW;  96E725BBB3D0736F CRC64;
     MARRTDRAPL LDWAEGPGVS PAPETEQGER WAQGYGAAWE RRPAGELTPL PQLEDDHIAA
     VFVVTFDPRS GNIVEWCRPH DIDLEGVEFK SMASGSHRVQ SDFIYFRKGG FFGLACFANM
     PVESELERGA RMKSVGVLSP SYTLLYRYMH FLENQVRHQL EIPGHYTPLE AFYEDKKGVL
     PVGPQTCQPA LHWLPPVHKH LYPEMKITHP AGCMSQFIKF FGEQIFVLWK FALLRKRILI
     FSPPPVGVVC YRVYCCCCLA NVTLPGIGAT APESKPFFYV NVADIQTLDG EGSYVACTTE
     KIFEQKQDLY DVYVDNQNVK THREHLQPLL RVNSADKEKY QRLNDQRQLL MYSQEVDGDC
     GSCEEDLFIL FFMEQNNRIF QTLLEVASSQ DKTLTAEHAR SMGLDPHGDR TFLMDLLEVY
     GFDLMLVIDN PCCP