DEN5A_HUMAN
ID DEN5A_HUMAN Reviewed; 1287 AA.
AC Q6IQ26; B4DJ15; E9PS91; Q96GN3; Q9H6U7; Q9UFV0; Q9UPR1;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=DENN domain-containing protein 5A;
DE AltName: Full=Rab6-interacting protein 1;
DE Short=Rab6IP1;
GN Name=DENND5A; Synonyms=KIAA1091, RAB6IP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-224.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 379-1287 (ISOFORM 1), AND VARIANT GLN-224.
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-224.
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.
RX PubMed=20937701; DOI=10.1083/jcb.201008051;
RA Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A.;
RT "Family-wide characterization of the DENN domain Rab GDP-GTP exchange
RT factors.";
RL J. Cell Biol. 191:367-381(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193; SER-1087 AND SER-1096,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP INVOLVEMENT IN DEE49.
RX PubMed=27866705; DOI=10.1016/j.ajhg.2016.10.006;
RA Han C., Alkhater R., Froukh T., Minassian A.G., Galati M., Liu R.H.,
RA Fotouhi M., Sommerfeld J., Alfrook A.J., Marshall C., Walker S., Bauer P.,
RA Scherer S.W., Riess O., Buchert R., Minassian B.A., McPherson P.S.;
RT "Epileptic encephalopathy caused by mutations in the guanine nucleotide
RT exchange factor DENND5A.";
RL Am. J. Hum. Genet. 99:1359-1367(2016).
RN [10]
RP VARIANT DEE49 GLY-541.
RX PubMed=27431290; DOI=10.1038/mp.2016.113;
RA Anazi S., Maddirevula S., Faqeih E., Alsedairy H., Alzahrani F.,
RA Shamseldin H.E., Patel N., Hashem M., Ibrahim N., Abdulwahab F., Ewida N.,
RA Alsaif H.S., Al Sharif H., Alamoudi W., Kentab A., Bashiri F.A.,
RA Alnaser M., AlWadei A.H., Alfadhel M., Eyaid W., Hashem A., Al Asmari A.,
RA Saleh M.M., AlSaman A., Alhasan K.A., Alsughayir M., Al Shammari M.,
RA Mahmoud A., Al-Hassnan Z.N., Al-Husain M., Osama Khalil R.,
RA Abd El Meguid N., Masri A., Ali R., Ben-Omran T., El Fishway P.,
RA Hashish A., Ercan Sencicek A., State M., Alazami A.M., Salih M.A.,
RA Altassan N., Arold S.T., Abouelhoda M., Wakil S.M., Monies D., Shaheen R.,
RA Alkuraya F.S.;
RT "Clinical genomics expands the morbid genome of intellectual disability and
RT offers a high diagnostic yield.";
RL Mol. Psychiatry 22:615-624(2017).
CC -!- FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate
CC RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP,
CC converting inactive GDP-bound Rab proteins into their active GTP-bound
CC form. Involved in the negative regulation of neurite outgrowth (By
CC similarity). {ECO:0000250|UniProtKB:G3V7Q0,
CC ECO:0000269|PubMed:20937701}.
CC -!- SUBUNIT: Interacts with RAB6A bound to GTP.
CC {ECO:0000250|UniProtKB:Q6PAL8}.
CC -!- INTERACTION:
CC Q6IQ26; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-2856768, EBI-5916454;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q6PAL8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6IQ26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6IQ26-2; Sequence=VSP_044688;
CC -!- DISEASE: Developmental and epileptic encephalopathy 49 (DEE49)
CC [MIM:617281]: A form of epileptic encephalopathy, a heterogeneous group
CC of severe early-onset epilepsies characterized by refractory seizures,
CC neurodevelopmental impairment, and poor prognosis. Development is
CC normal prior to seizure onset, after which cognitive and motor delays
CC become apparent. DEE49 is a severe autosomal recessive form
CC characterized by onset of seizures in the neonatal period, global
CC developmental delay, intellectual disability, and additionally cerebral
CC calcifications and coarse facial features.
CC {ECO:0000269|PubMed:27431290, ECO:0000269|PubMed:27866705}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83043.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB029014; BAA83043.1; ALT_INIT; mRNA.
DR EMBL; AK025499; BAB15155.1; ALT_INIT; mRNA.
DR EMBL; AK295881; BAG58677.1; -; mRNA.
DR EMBL; AL117448; CAB55932.2; -; mRNA.
DR EMBL; AC055845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP006259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009354; AAH09354.2; -; mRNA.
DR EMBL; BC071596; AAH71596.1; -; mRNA.
DR CCDS; CCDS31423.1; -. [Q6IQ26-1]
DR CCDS; CCDS58119.1; -. [Q6IQ26-2]
DR PIR; T17242; T17242.
DR RefSeq; NP_001230183.1; NM_001243254.1. [Q6IQ26-2]
DR RefSeq; NP_001335677.1; NM_001348748.1.
DR RefSeq; NP_056028.2; NM_015213.3. [Q6IQ26-1]
DR AlphaFoldDB; Q6IQ26; -.
DR SMR; Q6IQ26; -.
DR BioGRID; 116861; 19.
DR IntAct; Q6IQ26; 6.
DR MINT; Q6IQ26; -.
DR STRING; 9606.ENSP00000328524; -.
DR iPTMnet; Q6IQ26; -.
DR PhosphoSitePlus; Q6IQ26; -.
DR BioMuta; DENND5A; -.
DR DMDM; 317373354; -.
DR EPD; Q6IQ26; -.
DR jPOST; Q6IQ26; -.
DR MassIVE; Q6IQ26; -.
DR MaxQB; Q6IQ26; -.
DR PaxDb; Q6IQ26; -.
DR PeptideAtlas; Q6IQ26; -.
DR PRIDE; Q6IQ26; -.
DR ProteomicsDB; 23545; -.
DR ProteomicsDB; 66482; -. [Q6IQ26-1]
DR Antibodypedia; 24203; 115 antibodies from 20 providers.
DR DNASU; 23258; -.
DR Ensembl; ENST00000328194.8; ENSP00000328524.3; ENSG00000184014.9. [Q6IQ26-1]
DR Ensembl; ENST00000530044.5; ENSP00000435866.1; ENSG00000184014.9. [Q6IQ26-2]
DR GeneID; 23258; -.
DR KEGG; hsa:23258; -.
DR MANE-Select; ENST00000328194.8; ENSP00000328524.3; NM_015213.4; NP_056028.2.
DR UCSC; uc001mhl.5; human. [Q6IQ26-1]
DR CTD; 23258; -.
DR DisGeNET; 23258; -.
DR GeneCards; DENND5A; -.
DR HGNC; HGNC:19344; DENND5A.
DR HPA; ENSG00000184014; Low tissue specificity.
DR MalaCards; DENND5A; -.
DR MIM; 617278; gene.
DR MIM; 617281; phenotype.
DR neXtProt; NX_Q6IQ26; -.
DR OpenTargets; ENSG00000184014; -.
DR PharmGKB; PA164718737; -.
DR VEuPathDB; HostDB:ENSG00000184014; -.
DR eggNOG; KOG2080; Eukaryota.
DR GeneTree; ENSGT00940000153678; -.
DR HOGENOM; CLU_004201_2_0_1; -.
DR InParanoid; Q6IQ26; -.
DR OMA; KVTQEMY; -.
DR OrthoDB; 53600at2759; -.
DR PhylomeDB; Q6IQ26; -.
DR TreeFam; TF313237; -.
DR PathwayCommons; Q6IQ26; -.
DR Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR SignaLink; Q6IQ26; -.
DR BioGRID-ORCS; 23258; 10 hits in 1077 CRISPR screens.
DR ChiTaRS; DENND5A; human.
DR GenomeRNAi; 23258; -.
DR Pharos; Q6IQ26; Tbio.
DR PRO; PR:Q6IQ26; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IQ26; protein.
DR Bgee; ENSG00000184014; Expressed in corpus callosum and 198 other tissues.
DR ExpressionAtlas; Q6IQ26; baseline and differential.
DR Genevisible; Q6IQ26; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0010977; P:negative regulation of neuron projection development; ISS:UniProtKB.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF140741; SSF140741; 2.
DR SUPFAM; SSF49723; SSF49723; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; Epilepsy; Golgi apparatus;
KW Guanine-nucleotide releasing factor; Membrane; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..1287
FT /note="DENN domain-containing protein 5A"
FT /id="PRO_0000097142"
FT DOMAIN 57..259
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 278..414
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 416..598
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 787..950
FT /note="RUN 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT DOMAIN 954..1062
FT /note="PLAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00152"
FT DOMAIN 1134..1282
FT /note="RUN 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT REGION 681..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1079
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAL8"
FT MOD_RES 1085
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PAL8"
FT MOD_RES 1087
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1096
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1216..1287
FT /note="GKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVL
FT QTLQEFNITLETSLVKGIDI -> EITSYTTGLPCWLTAPSLHTCMRMWH (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044688"
FT VARIANT 224
FT /note="E -> Q (in dbSNP:rs952374)"
FT /evidence="ECO:0000269|PubMed:10470851,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_028409"
FT VARIANT 541
FT /note="D -> G (in DEE49; unknown pathological significance;
FT dbSNP:rs1057519309)"
FT /evidence="ECO:0000269|PubMed:27431290"
FT /id="VAR_078555"
FT CONFLICT 597
FT /note="K -> E (in Ref. 2; BAB15155)"
FT /evidence="ECO:0000305"
FT CONFLICT 929
FT /note="Q -> R (in Ref. 2; BAG58677)"
FT /evidence="ECO:0000305"
FT CONFLICT 998
FT /note="M -> V (in Ref. 2; BAG58677)"
FT /evidence="ECO:0000305"
FT CONFLICT 1100
FT /note="K -> E (in Ref. 2; BAB15155)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1287 AA; 147096 MW; 7633D36BE076C576 CRC64;
MSGGGGGGGS APSRFADYFV ICGLDTETGL EPDELSALCQ YIQASKARDG ASPFISSTTE
GENFEQTPLR RTFKSKVLAR YPENVEWNPF DQDAVGMLCM PKGLAFKTQA DPREPQFHAF
IITREDGSRT FGFALTFYEE VTSKQICSAM QTLYHMHNAE YDVLHAPPAD DRDQSSMEDG
EDTPVTKLQR FNSYDISRDT LYVSKCICLI TPMSFMKACR SVLEQLHQAV TSPQPPPLPL
ESYIYNVLYE VPLPPPGRSL KFSGVYGPII CQRPSTNELP LFDFPVKEVF ELLGVENVFQ
LFTCALLEFQ ILLYSQHYQR LMTVAETITA LMFPFQWQHV YVPILPASLL HFLDAPVPYL
MGLHSNGLDD RSKLELPQEA NLCFVDIDNH FIELPEDLPQ FPNKLEFVQE VSEILMAFGI
PPEGNLHCSE SASKLKRLRA SELVSDKRNG NIAGSPLHSY ELLKENETIA RLQALVKRTG
VSLEKLEVRE DPSSNKDLKV QCDEEELRIY QLNIQIREVF ANRFTQMFAD YEVFVIQPSQ
DKESWFTNRE QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDDDDKDPV
LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TVDEAEKAIE LRLAKIDHTA IHPHLLDMKI
GQGKYEPGFF PKLQSDVLST GPASNKWTKR NAPAQWRRKD RQKQHTEHLR LDNDQREKYI
QEARTMGSTI RQPKLSNLSP SVIAQTNWKF VEGLLKECRN KTKRMLVEKM GREAVELGHG
EVNITGVEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH LLHYQDNRQR KLTSGSLSTS
GILLDSERRK SDASSLMPPL RISLIQDMRH IQNIGEIKTD VGKARAWVRL SMEKKLLSRH
LKQLLSDHEL TKKLYKRYAF LRCDDEKEQF LYHLLSFNAV DYFCFTNVFT TILIPYHILI
VPSKKLGGSM FTANPWICIS GELGETQIMQ IPRNVLEMTF ECQNLGKLTT VQIGHDNSGL
YAKWLVEYVM VRNEITGHTY KFPCGRWLGK GMDDGSLERI LVGELLTSQP EVDERPCRTP
PLQQSPSVIR RLVTISPNNK PKLNTGQIQE SIGEAVNGIV KHFHKPEKER GSLTLLLCGE
CGLVSALEQA FQHGFKSPRL FKNVFIWDFL EKAQTYYETL EKNEVVPEEN WHTRARNFCR
FVTAINNTPR NIGKDGKFQM LVCLGARDHL LHHWIALLAD CPITAHMYED VALIKDHTLV
NSLIRVLQTL QEFNITLETS LVKGIDI
