ID   DEN6A_CHICK             Reviewed;         584 AA.
AC   Q5F3L4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein DENND6A;
DE   AltName: Full=DENN domain-containing protein 6A;
GN   Name=DENND6A; ORFNames=RCJMB04_14d15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DENND6 family. {ECO:0000305}.
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DR   EMBL; AJ851636; CAH65270.1; -; mRNA.
DR   RefSeq; NP_001012799.1; NM_001012781.1.
DR   AlphaFoldDB; Q5F3L4; -.
DR   STRING; 9031.ENSGALP00000009062; -.
DR   PaxDb; Q5F3L4; -.
DR   GeneID; 416006; -.
DR   KEGG; gga:416006; -.
DR   CTD; 201627; -.
DR   VEuPathDB; HostDB:geneid_416006; -.
DR   eggNOG; KOG2432; Eukaryota.
DR   InParanoid; Q5F3L4; -.
DR   OrthoDB; 252077at2759; -.
DR   PhylomeDB; Q5F3L4; -.
DR   PRO; PR:Q5F3L4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018307; ABL9/DENND6_dom.
DR   InterPro; IPR024224; DENND6.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR13677; PTHR13677; 1.
DR   Pfam; PF09794; Avl9; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Guanine-nucleotide releasing factor;
KW   Reference proteome.
FT   CHAIN           1..584
FT                   /note="Protein DENND6A"
FT                   /id="PRO_0000289118"
FT   DOMAIN          39..218
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          244..369
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          371..504
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  67051 MW;  EFED7536CF224F94 CRC64;
     MALWERGAGG AAEAGEDATE EPERGLPLLP WDRFSAWLHC VCVVGFDLEL GQAVEVIYPP
     HSKLTDKEKT NICYLSFPDS NSGCLGDTQF CFRFRRSSGR KASLCCFLDH LDRDLPVYLK
     KDPAYYYGYV YFRQVRDKSL KRGYFQKSLV LISKLPYIHL FRTVLKQIAP EYFEKSEAFL
     EAVCSDVDRW PPPVPGEVLH LPIMGVVMKL RIPTYRDKPG TTPVVQNMHQ ADAQISMTLP
     TVHEVDLFRC FCPVFFHIQM LWELVLLGEP LVVMAPSPAE SSETVLALVS CISPLKYCSD
     FRPYFTIHDS EFKEYTTRTQ APPSVILGVT NPFFAKTLQH WPHIIRIGDM KLPGDVPKQV
     KVKKLKNLKT LDSKPGVYTS YKPYLDKDEE IVKQLQKGVQ QKRPTEAQSA ILRRYFLELT
     ESFIIPLERY VASLMPLQKC ISPWKSPPQL RHFSQDDFMK TLEKAGPQLT SGLKGDWIGL
     YRHFLKSPNF DGWFRSRQKE MTQNLEALHL EALCNENLVF WSQKHTEVET VDLVLKLKNK
     LLQADREHLP VKTDTLKKLQ THIRDIILAL PDDLQDILLK TGTA