DENN_SCHPO
ID DENN_SCHPO Reviewed; 973 AA.
AC Q9Y7Q7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=DENN domain-containing protein C297.05;
GN ORFNames=SPCC297.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB40785.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-318 AND SER-726, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAB40785.1; -; Genomic_DNA.
DR PIR; T41272; T41272.
DR RefSeq; NP_588362.1; NM_001023353.2.
DR AlphaFoldDB; Q9Y7Q7; -.
DR BioGRID; 275790; 5.
DR STRING; 4896.SPCC297.05.1; -.
DR iPTMnet; Q9Y7Q7; -.
DR MaxQB; Q9Y7Q7; -.
DR PaxDb; Q9Y7Q7; -.
DR PRIDE; Q9Y7Q7; -.
DR EnsemblFungi; SPCC297.05.1; SPCC297.05.1:pep; SPCC297.05.
DR GeneID; 2539220; -.
DR KEGG; spo:SPCC297.05; -.
DR PomBase; SPCC297.05; -.
DR VEuPathDB; FungiDB:SPCC297.05; -.
DR eggNOG; ENOG502QQUM; Eukaryota.
DR HOGENOM; CLU_001932_0_0_1; -.
DR InParanoid; Q9Y7Q7; -.
DR OMA; RCEEWRK; -.
DR PhylomeDB; Q9Y7Q7; -.
DR Reactome; R-SPO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q9Y7Q7; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0019992; F:diacylglycerol binding; ISM:PomBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:PomBase.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; IBA:GO_Central.
DR GO; GO:0023052; P:signaling; NAS:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:PomBase.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..973
FT /note="DENN domain-containing protein C297.05"
FT /id="PRO_0000316866"
FT DOMAIN 169..427
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 449..586
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 588..919
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT REGION 69..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 134
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 726
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 973 AA; 109744 MW; 2C22DF3613BBA01A CRC64;
MESIADHFFL AGLSNGFVSV SNSQFRADRL DEDAISVSSS IIQNNTRKSP LKRVSITSES
SFYKENTFAH HNTTGSNSVG PKKPFLDYHH STSNTPTKKK KDSFDHASVT SLHRRSLSSN
TSTPRKYHSR KPYSEPSVID KEHLQNRVSI GTTHTQNDLY QSYVAYPDAL PLFAATHPFE
RRYPPSLLHQ FPSSKDIKNE TPTIDRCDFP NYVPMFAFPN DITIKESDVR PVSTYHSFAL
TSDNNSHLYG ICVVVWVAMP QSMQNDLEKE CEVWRANNTT VEDREVAEKL LSSLETERSK
LSSLLLKMQE KELEGSDSID PILLEKIDVC EENIILYTEL LRPMRYKLPR FVHGLTNNRT
LWIPNAYGLL SKHSHLQSFC RDWLRIVCSS IQAEDLDFIP SSDLNSLKSL NLQSFVKNIC
CDVPLPPKGL LQLQVNVGPL NLYAFRSPVN EIPGWNDVDL YPLFRALSIP NILVLFEAAL
MEAKVIFLSE NLGMLGYASQ ALLHLLYPLT WQGLYIPVLP RRLISCFEAP CSYIIGTLSY
FFHMDDVPLD NIPLVVCDLD KNSVSTFGKI VRLSRSLRSK LQAHLKLAAP LHDKFYVPHS
PPKYTMETYP NNVLSLSTVT CFPLREKFSI PALLSFRSSN FSKRPYVLSP ILNGFLKLQD
NPSSIYFAKQ TDSRQSSASK LLYARLQAPE HARNFSSPPF TRPASPSSSK FRFSSSSFQS
TIRRNSLTSP YSVPELRSSE SNQNKAGSIN TGSAVNLVSS KPGEQKVHIM YKEGHKLRRI
YKMFPADSAG SICAVSGYAL GDVHVQCDNC GLRVNLDFIK HISMPCVPAC FNSQQILVTF
LKFFIKILGS YRNYLRKPHM SRENFGISKG SGGLIGSFDF NKFTRQASKV HGSWISSLCS
SQAFAEFIGD RCELDLNDPR VALFDQLLLC ERNHGKPRLF GKATPFLRDK SLEIQRIEVA
PIPASLKNDN ALH
