DENR_DROME
ID DENR_DROME Reviewed; 189 AA.
AC Q9VX98; Q95SJ6;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Density-regulated protein homolog {ECO:0000303|PubMed:25043021};
GN Name=DENR {ECO:0000312|FlyBase:FBgn0030802};
GN ORFNames=CG9099 {ECO:0000312|FlyBase:FBgn0030802};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF48679.3};
RN [1] {ECO:0000312|EMBL:AAF48679.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAF48679.3}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL28305.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL28305.1};
RC TISSUE=Head {ECO:0000312|EMBL:AAL28305.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION, INTERACTION WITH MCTS1, AND DISRUPTION PHENOTYPE.
RX PubMed=25043021; DOI=10.1038/nature13401;
RA Schleich S., Strassburger K., Janiesch P.C., Koledachkina T., Miller K.K.,
RA Haneke K., Cheng Y.S., Kuchler K., Stoecklin G., Duncan K.E., Teleman A.A.;
RT "DENR-MCT-1 promotes translation re-initiation downstream of uORFs to
RT control tissue growth.";
RL Nature 512:208-212(2014).
CC -!- FUNCTION: Regulates translation as part of a complex with MCTS1.
CC Specifically required for translational re-initiation in mRNAs
CC containing upstream open reading frames (uORFs). Not required for
CC standard translational initiation. Regulates expression of a subset of
CC gene products including mbc, InR and EcR.
CC {ECO:0000269|PubMed:25043021}.
CC -!- SUBUNIT: Interacts with MCTS1. {ECO:0000269|PubMed:25043021}.
CC -!- DISRUPTION PHENOTYPE: Animals die as pharate adults with crooked legs,
CC abnormal genitalia and a larval-like epidermis. Proliferation of
CC histoblast cells is impaired. {ECO:0000269|PubMed:25043021}.
CC -!- SIMILARITY: Belongs to the DENR family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48679.3; -; Genomic_DNA.
DR EMBL; AE014298; AGB95472.1; -; Genomic_DNA.
DR EMBL; AY060757; AAL28305.1; -; mRNA.
DR RefSeq; NP_001259630.1; NM_001272701.1.
DR RefSeq; NP_573176.1; NM_132948.4.
DR AlphaFoldDB; Q9VX98; -.
DR SMR; Q9VX98; -.
DR IntAct; Q9VX98; 3.
DR STRING; 7227.FBpp0302657; -.
DR PaxDb; Q9VX98; -.
DR PRIDE; Q9VX98; -.
DR DNASU; 32679; -.
DR EnsemblMetazoa; FBtr0074347; FBpp0074121; FBgn0030802.
DR EnsemblMetazoa; FBtr0310520; FBpp0302657; FBgn0030802.
DR GeneID; 32679; -.
DR KEGG; dme:Dmel_CG9099; -.
DR UCSC; CG9099-RA; d. melanogaster.
DR CTD; 8562; -.
DR FlyBase; FBgn0030802; DENR.
DR VEuPathDB; VectorBase:FBgn0030802; -.
DR eggNOG; KOG3239; Eukaryota.
DR GeneTree; ENSGT00390000014349; -.
DR HOGENOM; CLU_073511_1_0_1; -.
DR InParanoid; Q9VX98; -.
DR OMA; EKWPQID; -.
DR OrthoDB; 1490022at2759; -.
DR PhylomeDB; Q9VX98; -.
DR BioGRID-ORCS; 32679; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 32679; -.
DR PRO; PR:Q9VX98; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030802; Expressed in spermathecum and 24 other tissues.
DR Genevisible; Q9VX98; DM.
DR GO; GO:0032991; C:protein-containing complex; IPI:FlyBase.
DR GO; GO:0048027; F:mRNA 5'-UTR binding; IDA:FlyBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:FlyBase.
DR GO; GO:0120142; P:positive regulation of ecdysone receptor-mediated signaling pathway; IMP:FlyBase.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IMP:FlyBase.
DR GO; GO:0002188; P:translation reinitiation; IDA:FlyBase.
DR InterPro; IPR005873; DENR_eukaryotes.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; SSF55159; 1.
DR TIGRFAMs; TIGR01159; DRP1; 1.
DR PROSITE; PS50296; SUI1; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Translation regulation.
FT CHAIN 1..189
FT /note="Density-regulated protein homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000432074"
FT DOMAIN 105..172
FT /note="SUI1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00200"
SQ SEQUENCE 189 AA; 21349 MW; 8FD869D637727C62 CRC64;
MTNEDVGTNS VADRLQLGPR EGVTYPIQMK YCGHCTMPIE YCEYYPEYEK CKEWLELHMP
DDFERLKIEE EAAAADGTDD DKKRQKRGGK GLLRVKKKED VPKRICVSRA ARGKKKSVTV
VTGLSTFDID LKVAAKFFGT KFACGSSVTG DDEIVIQGDV KDDLFDVIPE KWAEIDEDVI
EDLGDQKRT
